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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rx7 FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rx7 FOLDihydrofolate reductase 1.5.1.3 1.021
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.907
1dyh DZFDihydrofolate reductase 1.5.1.3 0.887
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.880
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.863
7dfr FOLDihydrofolate reductase 1.5.1.3 0.859
4x5g FOLDihydrofolate reductase 1.5.1.3 0.857
4x5f FOLDihydrofolate reductase 1.5.1.3 0.853
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.846
1dyi FOLDihydrofolate reductase 1.5.1.3 0.840
4fhb FOLDihydrofolate reductase 1.5.1.3 0.839
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.829
4i1n FOLDihydrofolate reductase 1.5.1.3 0.826
1dyj DDFDihydrofolate reductase 1.5.1.3 0.820
4kjj FOLDihydrofolate reductase 1.5.1.3 0.820
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.809
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.809
4m6k FOLDihydrofolate reductase 1.5.1.3 0.805
1re7 FOLDihydrofolate reductase 1.5.1.3 0.800
4kfj FOLDihydrofolate reductase 1.5.1.3 0.800
2w3m FOLDihydrofolate reductase 1.5.1.3 0.797
2zza FOLDihydrofolate reductase / 0.796
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.794
4i13 FOLDihydrofolate reductase 1.5.1.3 0.794
4keb FOLDihydrofolate reductase 1.5.1.3 0.794
1drf FOLDihydrofolate reductase 1.5.1.3 0.789
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.788
3tqb FOLDihydrofolate reductase / 0.785
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.781
4x5h FOLDihydrofolate reductase 1.5.1.3 0.781
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.777
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.776
1hfq MOTDihydrofolate reductase 1.5.1.3 0.772
2d0k FOLDihydrofolate reductase 1.5.1.3 0.772
1hfr MOTDihydrofolate reductase 1.5.1.3 0.771
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.771
1dhf FOLDihydrofolate reductase 1.5.1.3 0.767
4x5i FOLDihydrofolate reductase 1.5.1.3 0.766
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.762
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.760
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.758
1u72 MTXDihydrofolate reductase 1.5.1.3 0.756
1jom FFODihydrofolate reductase 1.5.1.3 0.754
5hi6 MTXDihydrofolate reductase / 0.744
1hfp MOTDihydrofolate reductase 1.5.1.3 0.740
1dhj MTXDihydrofolate reductase 1.5.1.3 0.739
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.735
1dre MTXDihydrofolate reductase 1.5.1.3 0.733
3ghw GHWDihydrofolate reductase 1.5.1.3 0.733
4m6l 21VDihydrofolate reductase 1.5.1.3 0.731
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.730
1df7 MTXDihydrofolate reductase 1.5.1.3 0.728
3eig MTXDihydrofolate reductase 1.5.1.3 0.728
1tdr MTXDihydrofolate reductase 1.5.1.3 0.726
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.724
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.720
1u70 MTXDihydrofolate reductase 1.5.1.3 0.719
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.718
1e26 GPBDihydrofolate reductase 1.5.1.3 0.717
4dfr MTXDihydrofolate reductase 1.5.1.3 0.713
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.710
4qi9 MTXDihydrofolate reductase / 0.709
1dls MTXDihydrofolate reductase 1.5.1.3 0.702
1drb MTXDihydrofolate reductase 1.5.1.3 0.701
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.696
3tq9 MTXDihydrofolate reductase / 0.696
1dra MTXDihydrofolate reductase 1.5.1.3 0.695
2qk8 MTXDihydrofolate reductase / 0.694
2drc MTXDihydrofolate reductase 1.5.1.3 0.693
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.691
3drc MTXDihydrofolate reductase 1.5.1.3 0.691
4p66 MTXDihydrofolate reductase / 0.691
1dhi MTXDihydrofolate reductase 1.5.1.3 0.690
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.690
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.690
2dhf DZFDihydrofolate reductase 1.5.1.3 0.688
4eil FOLBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.685
3dau MTXDihydrofolate reductase 1.5.1.3 0.684
3och 2MXDihydrofolate reductase 1.5.1.3 0.679
3ia4 MTXDihydrofolate reductase / 0.678
4p68 MTXDihydrofolate reductase / 0.671
1ohj COPDihydrofolate reductase 1.5.1.3 0.665
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.665
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.661
5ccc DDFDihydrofolate reductase 1.5.1.3 0.656
3dfr MTXDihydrofolate reductase 1.5.1.3 0.652
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.650
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.650