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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rx5 DDF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rx5 DDFDihydrofolate reductase 1.5.1.3 1.100
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.884
7dfr FOLDihydrofolate reductase 1.5.1.3 0.884
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.865
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.863
4x5f FOLDihydrofolate reductase 1.5.1.3 0.841
1dyh DZFDihydrofolate reductase 1.5.1.3 0.832
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.832
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.804
4i1n FOLDihydrofolate reductase 1.5.1.3 0.795
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.789
4qi9 MTXDihydrofolate reductase / 0.789
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.785
1dyj DDFDihydrofolate reductase 1.5.1.3 0.782
4keb FOLDihydrofolate reductase 1.5.1.3 0.775
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.774
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.765
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.764
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.756
1dre MTXDihydrofolate reductase 1.5.1.3 0.754
1jom FFODihydrofolate reductase 1.5.1.3 0.754
3eig MTXDihydrofolate reductase 1.5.1.3 0.752
4fhb FOLDihydrofolate reductase 1.5.1.3 0.750
1jol FFODihydrofolate reductase 1.5.1.3 0.748
2d0k FOLDihydrofolate reductase 1.5.1.3 0.747
4m6k FOLDihydrofolate reductase 1.5.1.3 0.745
1u72 MTXDihydrofolate reductase 1.5.1.3 0.743
1dhj MTXDihydrofolate reductase 1.5.1.3 0.741
4x5g FOLDihydrofolate reductase 1.5.1.3 0.741
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.740
4kfj FOLDihydrofolate reductase 1.5.1.3 0.740
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.739
1drb MTXDihydrofolate reductase 1.5.1.3 0.737
1e26 GPBDihydrofolate reductase 1.5.1.3 0.737
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.735
4kjj FOLDihydrofolate reductase 1.5.1.3 0.732
3tq9 MTXDihydrofolate reductase / 0.730
1dyi FOLDihydrofolate reductase 1.5.1.3 0.726
2zza FOLDihydrofolate reductase / 0.726
3dfr MTXDihydrofolate reductase 1.5.1.3 0.725
1hfr MOTDihydrofolate reductase 1.5.1.3 0.722
1ohj COPDihydrofolate reductase 1.5.1.3 0.721
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.720
4i13 FOLDihydrofolate reductase 1.5.1.3 0.720
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.717
2w3m FOLDihydrofolate reductase 1.5.1.3 0.716
1hfq MOTDihydrofolate reductase 1.5.1.3 0.715
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.715
3frd DHFDihydrofolate reductase 1.5.1.3 0.715
1re7 FOLDihydrofolate reductase 1.5.1.3 0.713
3ghw GHWDihydrofolate reductase 1.5.1.3 0.710
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.709
5hi6 MTXDihydrofolate reductase / 0.709
1dhf FOLDihydrofolate reductase 1.5.1.3 0.705
1dhi MTXDihydrofolate reductase 1.5.1.3 0.704
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.704
4m6l 21VDihydrofolate reductase 1.5.1.3 0.704
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.703
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.699
1df7 MTXDihydrofolate reductase 1.5.1.3 0.698
1hfp MOTDihydrofolate reductase 1.5.1.3 0.697
1drf FOLDihydrofolate reductase 1.5.1.3 0.696
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.691
3ia4 MTXDihydrofolate reductase / 0.691
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.689
4p66 MTXDihydrofolate reductase / 0.688
1ddr MTXDihydrofolate reductase 1.5.1.3 0.687
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.685
4x5h FOLDihydrofolate reductase 1.5.1.3 0.685
4p68 MTXDihydrofolate reductase / 0.684
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.681
3tqb FOLDihydrofolate reductase / 0.680
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.678
3ghv GHCDihydrofolate reductase 1.5.1.3 0.674
2dhf DZFDihydrofolate reductase 1.5.1.3 0.672
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.671
2drc MTXDihydrofolate reductase 1.5.1.3 0.667
3dau MTXDihydrofolate reductase 1.5.1.3 0.667
3och 2MXDihydrofolate reductase 1.5.1.3 0.665
3r02 UNMSerine/threonine-protein kinase pim-1 2.7.11.1 0.665
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.664
1dds MTXDihydrofolate reductase 1.5.1.3 0.663
3to3 ATPPetrobactin biosynthesis protein AsbB / 0.662
4x5i FOLDihydrofolate reductase 1.5.1.3 0.662
1u70 MTXDihydrofolate reductase 1.5.1.3 0.661
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.659
4yao 2AMNADPH--cytochrome P450 reductase / 0.659
3drc MTXDihydrofolate reductase 1.5.1.3 0.654
1daj MOTDihydrofolate reductase 1.5.1.3 0.653
1tdr MTXDihydrofolate reductase 1.5.1.3 0.650
3b1d PLSBetaC-S lyase / 0.650