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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rx4 DDF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rx4 DDFDihydrofolate reductase 1.5.1.3 1.175
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.983
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.884
5ccc DDFDihydrofolate reductase 1.5.1.3 0.842
1dyj DDFDihydrofolate reductase 1.5.1.3 0.827
1hfr MOTDihydrofolate reductase 1.5.1.3 0.827
1hfq MOTDihydrofolate reductase 1.5.1.3 0.815
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.796
7dfr FOLDihydrofolate reductase 1.5.1.3 0.795
1dyh DZFDihydrofolate reductase 1.5.1.3 0.786
1dyi FOLDihydrofolate reductase 1.5.1.3 0.783
1jol FFODihydrofolate reductase 1.5.1.3 0.781
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.781
1hfp MOTDihydrofolate reductase 1.5.1.3 0.777
1jom FFODihydrofolate reductase 1.5.1.3 0.774
4m6k FOLDihydrofolate reductase 1.5.1.3 0.773
1e26 GPBDihydrofolate reductase 1.5.1.3 0.770
4i13 FOLDihydrofolate reductase 1.5.1.3 0.769
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.763
2d0k FOLDihydrofolate reductase 1.5.1.3 0.760
4keb FOLDihydrofolate reductase 1.5.1.3 0.755
2drc MTXDihydrofolate reductase 1.5.1.3 0.753
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.752
4x5i FOLDihydrofolate reductase 1.5.1.3 0.749
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.740
1df7 MTXDihydrofolate reductase 1.5.1.3 0.737
3tqb FOLDihydrofolate reductase / 0.737
4dfr MTXDihydrofolate reductase 1.5.1.3 0.736
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.734
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.733
4kfj FOLDihydrofolate reductase 1.5.1.3 0.732
1dhi MTXDihydrofolate reductase 1.5.1.3 0.725
3ia4 MTXDihydrofolate reductase / 0.724
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.724
1dhj MTXDihydrofolate reductase 1.5.1.3 0.723
1drb MTXDihydrofolate reductase 1.5.1.3 0.722
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.722
4m6l 21VDihydrofolate reductase 1.5.1.3 0.722
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.717
1u72 MTXDihydrofolate reductase 1.5.1.3 0.717
3eig MTXDihydrofolate reductase 1.5.1.3 0.717
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.716
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.714
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.713
2w3m FOLDihydrofolate reductase 1.5.1.3 0.712
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.709
3ghw GHWDihydrofolate reductase 1.5.1.3 0.708
4i1n FOLDihydrofolate reductase 1.5.1.3 0.704
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.700
1dre MTXDihydrofolate reductase 1.5.1.3 0.697
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.696
1ddr MTXDihydrofolate reductase 1.5.1.3 0.695
1u70 MTXDihydrofolate reductase 1.5.1.3 0.695
2dhf DZFDihydrofolate reductase 1.5.1.3 0.694
1ohj COPDihydrofolate reductase 1.5.1.3 0.691
3drc MTXDihydrofolate reductase 1.5.1.3 0.687
2zza FOLDihydrofolate reductase / 0.686
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.686
1tdr MTXDihydrofolate reductase 1.5.1.3 0.685
4p68 MTXDihydrofolate reductase / 0.685
3dau MTXDihydrofolate reductase 1.5.1.3 0.683
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.682
1dhf FOLDihydrofolate reductase 1.5.1.3 0.680
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.677
4fhb FOLDihydrofolate reductase 1.5.1.3 0.676
4p66 MTXDihydrofolate reductase / 0.673
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.672
4qi9 MTXDihydrofolate reductase / 0.672
4y9r NAPNADPH--cytochrome P450 reductase / 0.672
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.671
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.670
3och 2MXDihydrofolate reductase 1.5.1.3 0.670
4x5g FOLDihydrofolate reductase 1.5.1.3 0.668
1drf FOLDihydrofolate reductase 1.5.1.3 0.665
1toi HCIAspartate aminotransferase 2.6.1.1 0.664
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.663
1re7 FOLDihydrofolate reductase 1.5.1.3 0.663
5hi6 MTXDihydrofolate reductase / 0.659
4x5h FOLDihydrofolate reductase 1.5.1.3 0.658
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.657
4bqw QNMEgl nine homolog 1 / 0.657
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.656
1dra MTXDihydrofolate reductase 1.5.1.3 0.655
2hxd DUPdCTP deaminase, dUMP-forming 3.5.4.30 0.655
1dls MTXDihydrofolate reductase 1.5.1.3 0.653
3frd DHFDihydrofolate reductase 1.5.1.3 0.652