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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rx3 MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rx3 MTXDihydrofolate reductase 1.5.1.3 1.117
1df7 MTXDihydrofolate reductase 1.5.1.3 0.855
4dfr MTXDihydrofolate reductase 1.5.1.3 0.853
4p66 MTXDihydrofolate reductase / 0.851
3och 2MXDihydrofolate reductase 1.5.1.3 0.849
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.848
3ia4 MTXDihydrofolate reductase / 0.846
5hi6 MTXDihydrofolate reductase / 0.845
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.843
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.832
3dau MTXDihydrofolate reductase 1.5.1.3 0.830
2drc MTXDihydrofolate reductase 1.5.1.3 0.828
1dls MTXDihydrofolate reductase 1.5.1.3 0.824
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.820
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.816
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.814
1dre MTXDihydrofolate reductase 1.5.1.3 0.812
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.805
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.804
1dhi MTXDihydrofolate reductase 1.5.1.3 0.803
1dra MTXDihydrofolate reductase 1.5.1.3 0.803
1drb MTXDihydrofolate reductase 1.5.1.3 0.803
3tq9 MTXDihydrofolate reductase / 0.797
1u70 MTXDihydrofolate reductase 1.5.1.3 0.796
2qk8 MTXDihydrofolate reductase / 0.793
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.793
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.786
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.786
3drc MTXDihydrofolate reductase 1.5.1.3 0.784
1hfr MOTDihydrofolate reductase 1.5.1.3 0.782
4qi9 MTXDihydrofolate reductase / 0.781
2zza FOLDihydrofolate reductase / 0.777
4kjj FOLDihydrofolate reductase 1.5.1.3 0.773
1hfq MOTDihydrofolate reductase 1.5.1.3 0.772
3eig MTXDihydrofolate reductase 1.5.1.3 0.770
1dyi FOLDihydrofolate reductase 1.5.1.3 0.769
4i1n FOLDihydrofolate reductase 1.5.1.3 0.767
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.766
1tdr MTXDihydrofolate reductase 1.5.1.3 0.765
3dfr MTXDihydrofolate reductase 1.5.1.3 0.765
1jol FFODihydrofolate reductase 1.5.1.3 0.759
5ccc DDFDihydrofolate reductase 1.5.1.3 0.759
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.757
3frd DHFDihydrofolate reductase 1.5.1.3 0.756
4i13 FOLDihydrofolate reductase 1.5.1.3 0.755
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.754
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.754
4p68 MTXDihydrofolate reductase / 0.753
1re7 FOLDihydrofolate reductase 1.5.1.3 0.752
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.752
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.744
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.744
1u72 MTXDihydrofolate reductase 1.5.1.3 0.744
2w3m FOLDihydrofolate reductase 1.5.1.3 0.744
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.743
1drf FOLDihydrofolate reductase 1.5.1.3 0.743
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.742
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.742
4x5g FOLDihydrofolate reductase 1.5.1.3 0.739
4x5f FOLDihydrofolate reductase 1.5.1.3 0.737
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.735
4x5h FOLDihydrofolate reductase 1.5.1.3 0.735
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.732
4fhb FOLDihydrofolate reductase 1.5.1.3 0.731
1dyh DZFDihydrofolate reductase 1.5.1.3 0.730
7dfr FOLDihydrofolate reductase 1.5.1.3 0.728
1dhj MTXDihydrofolate reductase 1.5.1.3 0.727
1hfp MOTDihydrofolate reductase 1.5.1.3 0.724
2d0k FOLDihydrofolate reductase 1.5.1.3 0.721
1jom FFODihydrofolate reductase 1.5.1.3 0.720
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.720
4kfj FOLDihydrofolate reductase 1.5.1.3 0.717
1dyj DDFDihydrofolate reductase 1.5.1.3 0.716
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.715
3dat MTXDihydrofolate reductase / 0.712
4x5i FOLDihydrofolate reductase 1.5.1.3 0.712
1dhf FOLDihydrofolate reductase 1.5.1.3 0.711
1ohj COPDihydrofolate reductase 1.5.1.3 0.709
3ghw GHWDihydrofolate reductase 1.5.1.3 0.697
1dds MTXDihydrofolate reductase 1.5.1.3 0.695
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.691
1ddr MTXDihydrofolate reductase 1.5.1.3 0.690
2dhf DZFDihydrofolate reductase 1.5.1.3 0.690
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.686
4m6k FOLDihydrofolate reductase 1.5.1.3 0.683
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.677
4m6l 21VDihydrofolate reductase 1.5.1.3 0.677
3m08 RARDihydrofolate reductase 1.5.1.3 0.675
3ldw IPEFarnesyl pyrophosphate synthase, putative / 0.674
1ohk COPDihydrofolate reductase 1.5.1.3 0.673
4keb FOLDihydrofolate reductase 1.5.1.3 0.671
1e26 GPBDihydrofolate reductase 1.5.1.3 0.670
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.661
4elf 35IDihydrofolate reductase / 0.658
1hbn TP7Methyl-coenzyme M reductase I subunit alpha 2.8.4.1 0.655
1hbn TP7Methyl-coenzyme M reductase I subunit beta 2.8.4.1 0.655
3tqb FOLDihydrofolate reductase / 0.652