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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1riw OSC Prothrombin 3.4.21.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1riw OSCProthrombin 3.4.21.5 1.243
2gde SN3Prothrombin 3.4.21.5 1.004
2zda 32UProthrombin 3.4.21.5 0.922
2zhq 27UProthrombin 3.4.21.5 0.905
1k22 MELProthrombin 3.4.21.5 0.851
2zi2 24UProthrombin 3.4.21.5 0.851
2zg0 50UProthrombin 3.4.21.5 0.841
2zgx 29UProthrombin 3.4.21.5 0.841
2zhf 49UProthrombin 3.4.21.5 0.838
2zfq 45UProthrombin 3.4.21.5 0.833
4ban M6SProthrombin 3.4.21.5 0.827
4bam MM9Prothrombin 3.4.21.5 0.826
1k21 IGNProthrombin 3.4.21.5 0.825
4bao MVFProthrombin 3.4.21.5 0.825
2a2x NA9Prothrombin 3.4.21.5 0.824
1ypl RA8Prothrombin 3.4.21.5 0.815
3utu 1TSProthrombin 3.4.21.5 0.804
2zhe 13UProthrombin 3.4.21.5 0.803
2ziq 26UProthrombin 3.4.21.5 0.801
4baq M4ZProthrombin 3.4.21.5 0.799
2zff 53UProthrombin 3.4.21.5 0.798
1ypk CCRProthrombin 3.4.21.5 0.787
3hat GLY_VAL_ARG_RNGProthrombin 3.4.21.5 0.785
2zdv 37UProthrombin 3.4.21.5 0.779
4bah MELProthrombin 3.4.21.5 0.779
1nzq 162Prothrombin 3.4.21.5 0.776
1ypm RA4Prothrombin 3.4.21.5 0.773
3dhk 23UProthrombin 3.4.21.5 0.773
2zfr 46UProthrombin 3.4.21.5 0.771
2zf0 51UProthrombin 3.4.21.5 0.768
2znk 31UProthrombin 3.4.21.5 0.767
1zsk 421Coagulation factor XI 3.4.21.27 0.764
1ae8 AZLProthrombin 3.4.21.5 0.762
2zc9 22UProthrombin 3.4.21.5 0.762
3qwc 98PProthrombin 3.4.21.5 0.760
3plp BBACationic trypsin 3.4.21.4 0.759
3qtv 06PProthrombin 3.4.21.5 0.759
5cmx 0G6Prothrombin 3.4.21.5 0.759
2bdy UNBProthrombin 3.4.21.5 0.757
2zp0 PI0Coagulation factor VII 3.4.21.21 0.752
3biu 10UProthrombin 3.4.21.5 0.752
2anm CDOProthrombin 3.4.21.5 0.750
4bak M67Prothrombin 3.4.21.5 0.745
3v0x ANHCationic trypsin 3.4.21.4 0.740
4e7r 0NWProthrombin 3.4.21.5 0.740
1c5n ESIProthrombin 3.4.21.5 0.739
4az2 9MUProthrombin 3.4.21.5 0.738
1c4u IH1Prothrombin 3.4.21.5 0.735
1wtg 3BPCoagulation factor VII 3.4.21.21 0.727
4ax9 N5NProthrombin 3.4.21.5 0.727
3p17 99PProthrombin 3.4.21.5 0.726
3qto 10PProthrombin 3.4.21.5 0.723
1vja 7INUrokinase-type plasminogen activator 3.4.21.73 0.721
4ayy 9MXProthrombin 3.4.21.5 0.721
1ypj UIBProthrombin 3.4.21.5 0.711
1wv7 5PICoagulation factor VII 3.4.21.21 0.709
1ghv 120Prothrombin 3.4.21.5 0.703
2zhw 12UProthrombin 3.4.21.5 0.703
4ayv 9MQProthrombin 3.4.21.5 0.701
1vzq SHYProthrombin 3.4.21.5 0.698
1w13 SM1Urokinase-type plasminogen activator 3.4.21.73 0.694
2zfp 19UProthrombin 3.4.21.5 0.691
2c4f GILCoagulation factor VII 3.4.21.21 0.685
1wqv PSMCoagulation factor VII 3.4.21.21 0.683
1gmc PRO_GLY_ALA_TYRChymotrypsinogen A 3.4.21.1 0.682
1f92 UKPUrokinase-type plasminogen activator 3.4.21.73 0.680
3qdz PRO_ALA_PRO_ARGProthrombin 3.4.21.5 0.680
4fub 4UPUrokinase-type plasminogen activator 3.4.21.73 0.679
1oyt FSNProthrombin 3.4.21.5 0.678
1d4p BPPProthrombin 3.4.21.5 0.673
3ens ENSCoagulation factor X 3.4.21.6 0.673
1lpk CBBCoagulation factor X 3.4.21.6 0.672
1o0d 163Prothrombin 3.4.21.5 0.671
4fuj 1U9Urokinase-type plasminogen activator 3.4.21.73 0.668
4d8n 0HMKallikrein-6 3.4.21 0.667
1xm1 GAHProthrombin 3.4.21.5 0.662
2cf8 ESHProthrombin 3.4.21.5 0.662
1ta2 176Prothrombin 3.4.21.5 0.658
2cf9 348Prothrombin 3.4.21.5 0.658
1uvs I11Prothrombin 3.4.21.5 0.657
1t4v 14AProthrombin 3.4.21.5 0.655
3dux 64UProthrombin 3.4.21.5 0.655
2cn0 F25Prothrombin 3.4.21.5 0.652
1c4v IH2Prothrombin 3.4.21.5 0.651
2v3h I25Prothrombin 3.4.21.5 0.651