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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rc4 DDF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1rc4 DDFDihydrofolate reductase 1.5.1.3 1.016
5ccc DDFDihydrofolate reductase 1.5.1.3 0.866
1dyi FOLDihydrofolate reductase 1.5.1.3 0.843
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.838
1dyj DDFDihydrofolate reductase 1.5.1.3 0.829
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.827
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.825
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.821
4x5g FOLDihydrofolate reductase 1.5.1.3 0.820
7dfr FOLDihydrofolate reductase 1.5.1.3 0.817
4kjj FOLDihydrofolate reductase 1.5.1.3 0.815
1re7 FOLDihydrofolate reductase 1.5.1.3 0.801
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.800
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.796
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.789
4i13 FOLDihydrofolate reductase 1.5.1.3 0.788
4m6k FOLDihydrofolate reductase 1.5.1.3 0.788
4i1n FOLDihydrofolate reductase 1.5.1.3 0.781
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.775
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.768
1e26 GPBDihydrofolate reductase 1.5.1.3 0.767
3drc MTXDihydrofolate reductase 1.5.1.3 0.764
1hfr MOTDihydrofolate reductase 1.5.1.3 0.760
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.759
3tq9 MTXDihydrofolate reductase / 0.759
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.758
3tqb FOLDihydrofolate reductase / 0.752
1jol FFODihydrofolate reductase 1.5.1.3 0.750
1hfq MOTDihydrofolate reductase 1.5.1.3 0.748
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.744
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.742
1dhf FOLDihydrofolate reductase 1.5.1.3 0.741
4qi9 MTXDihydrofolate reductase / 0.741
3och 2MXDihydrofolate reductase 1.5.1.3 0.740
5hi6 MTXDihydrofolate reductase / 0.738
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.736
4keb FOLDihydrofolate reductase 1.5.1.3 0.735
2zza FOLDihydrofolate reductase / 0.731
2d0k FOLDihydrofolate reductase 1.5.1.3 0.730
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.730
4kfj FOLDihydrofolate reductase 1.5.1.3 0.730
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.726
4x5h FOLDihydrofolate reductase 1.5.1.3 0.726
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.723
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.722
1drf FOLDihydrofolate reductase 1.5.1.3 0.719
2w3m FOLDihydrofolate reductase 1.5.1.3 0.719
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.718
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.718
4dfr MTXDihydrofolate reductase 1.5.1.3 0.716
1drb MTXDihydrofolate reductase 1.5.1.3 0.714
4m6l 21VDihydrofolate reductase 1.5.1.3 0.708
2drc MTXDihydrofolate reductase 1.5.1.3 0.701
1dra MTXDihydrofolate reductase 1.5.1.3 0.700
1dhi MTXDihydrofolate reductase 1.5.1.3 0.699
1hfp MOTDihydrofolate reductase 1.5.1.3 0.699
3frd DHFDihydrofolate reductase 1.5.1.3 0.699
1df7 MTXDihydrofolate reductase 1.5.1.3 0.698
4x5f FOLDihydrofolate reductase 1.5.1.3 0.696
1dhj MTXDihydrofolate reductase 1.5.1.3 0.695
1tdr MTXDihydrofolate reductase 1.5.1.3 0.694
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.692
3dfr MTXDihydrofolate reductase 1.5.1.3 0.690
3eig MTXDihydrofolate reductase 1.5.1.3 0.687
4fhb FOLDihydrofolate reductase 1.5.1.3 0.683
3dau MTXDihydrofolate reductase 1.5.1.3 0.682
1jom FFODihydrofolate reductase 1.5.1.3 0.680
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.680
4p68 MTXDihydrofolate reductase / 0.679
3dat MTXDihydrofolate reductase / 0.675
1dre MTXDihydrofolate reductase 1.5.1.3 0.672
2qk8 MTXDihydrofolate reductase / 0.671
3ghv GHCDihydrofolate reductase 1.5.1.3 0.671
1u70 MTXDihydrofolate reductase 1.5.1.3 0.670
3ghw GHWDihydrofolate reductase 1.5.1.3 0.668
1drt PCVClavaminate synthase 1 1.14.11.21 0.663
1dyh DZFDihydrofolate reductase 1.5.1.3 0.663
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.663
1u72 MTXDihydrofolate reductase 1.5.1.3 0.661
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.658
1x28 PGUAspartate aminotransferase 2.6.1.1 0.657
4x5i FOLDihydrofolate reductase 1.5.1.3 0.657
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.656
3aej AA5Methionine gamma-lyase / 0.655
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.654
1ohj COPDihydrofolate reductase 1.5.1.3 0.653
1ddr MTXDihydrofolate reductase 1.5.1.3 0.652
2dhf DZFDihydrofolate reductase 1.5.1.3 0.651
4ie5 MD6Alpha-ketoglutarate-dependent dioxygenase FTO / 0.651
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.650