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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1qyw 5SD Estradiol 17-beta-dehydrogenase 1 1.1.1.62

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.988
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.857
3dey DHTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.770
3klm DHTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.770
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.734
1t79 DHTAndrogen receptor / 0.725
2pip DHTAndrogen receptor / 0.725
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.723
4oez DHTAndrogen receptor / 0.721
4ofr DHTAndrogen receptor / 0.718
1t5z DHTAndrogen receptor / 0.709
1t7r DHTAndrogen receptor / 0.706
2pit DHTAndrogen receptor / 0.706
1t74 DHTAndrogen receptor / 0.705
2pio DHTAndrogen receptor / 0.705
1t73 DHTAndrogen receptor / 0.704
2ama DHTAndrogen receptor / 0.701
4oey DHTAndrogen receptor / 0.699
2piq DHTAndrogen receptor / 0.698
4oea DHTAndrogen receptor / 0.697
4c49 HCYCorticosteroid-binding globulin / 0.694
2q7i TESAndrogen receptor / 0.690
2q7k TESAndrogen receptor / 0.689
2j7y E3OEstrogen receptor beta / 0.687
1t7f DHTAndrogen receptor / 0.686
1t76 DHTAndrogen receptor / 0.685
2ylp TESAndrogen receptor / 0.685
1xj7 DHTAndrogen receptor / 0.684
2z4j DHTAndrogen receptor / 0.684
3zqt TESAndrogen receptor / 0.680
3uzz TES3-oxo-5-beta-steroid 4-dehydrogenase / 0.676
3gyu DL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily / 0.671
1t7m DHTAndrogen receptor / 0.670
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.666
1lhw ESMSex hormone-binding globulin / 0.664
2qd4 CHDFerrochelatase, mitochondrial 4.99.1.1 0.664
3m8c EQUSteroid Delta-isomerase 5.3.3.1 0.662
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pkl DHTAndrogen receptor / 0.654
2q7l TESAndrogen receptor / 0.654
4hlw TESAndrogen receptor / 0.654
4l1x STRAldo-keto reductase family 1 member C2 / 0.654
2piu DHTAndrogen receptor / 0.652
1zhw HC2Oxysterol-binding protein homolog 4 / 0.651
4klr CHDFerrochelatase, mitochondrial 4.99.1.1 0.651
1gs4 ZK5Androgen receptor / 0.650