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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1q8w M77 cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1q8w M77cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.917
2gnl H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.751
2c1b CQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.725
2f2u M77Rho-associated protein kinase 2 2.7.11.1 0.723
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
1q8u H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
1ydt IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.713
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
2gnh H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
2gni M77cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.665
1rej B1LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.654
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.652
3nuy JPZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651