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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1q45 FMN 12-oxophytodienoate reductase 3 1.3.1.42

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 1.275
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 1.167
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 1.165
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 1.148
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 1.147
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 1.047
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 1.007
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.985
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.959
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.952
3l67 FMNXenobiotic reductase / 0.945
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.944
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.926
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.921
4utm FNRXenobiotic reductase / 0.921
3tjl FMNNADPH dehydrogenase / 0.920
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.915
3p62 FMNPentaerythritol tetranitrate reductase / 0.914
4utl FNRXenobiotic reductase / 0.913
2abb FMNPentaerythritol tetranitrate reductase / 0.904
3p84 FMNPentaerythritol tetranitrate reductase / 0.894
4uth FMNXenobiotic reductase / 0.891
5cpm FNRNADH:flavin oxidoreductase / 0.891
3n19 FNRXenobiotic reductase / 0.890
4utk FNRXenobiotic reductase / 0.889
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.888
1z41 FMNNADPH dehydrogenase / 0.887
2h8x FMNXenA / 0.875
4e2d FMNDehydrogenase / 0.867
3p74 FMNPentaerythritol tetranitrate reductase / 0.864
2zfa FMNLactate oxidase / 0.863
3l5l FMNXenobiotic reductase / 0.861
4df2 FMNNADPH dehydrogenase / 0.858
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.858
1h50 FMNPentaerythritol tetranitrate reductase / 0.855
1vhn FMNtRNA-dihydrouridine synthase / 0.852
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.847
4m5p FMNNADPH dehydrogenase / 0.845
4tmc FMNOld yellow enzyme / 0.842
1vyr FMNPentaerythritol tetranitrate reductase / 0.839
2nli FMNLactate oxidase / 0.838
3f03 FMNPentaerythritol tetranitrate reductase / 0.838
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.838
3p8i FMNPentaerythritol tetranitrate reductase / 0.837
4yl2 FMNLactate oxidase / 0.837
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.835
1h51 FMNPentaerythritol tetranitrate reductase / 0.834
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.832
4tmb FMNOld yellow enzyme / 0.830
1h63 FMNPentaerythritol tetranitrate reductase / 0.829
1z48 FMNNADPH dehydrogenase / 0.828
1gwj FMNMorphinone reductase / 0.820
2z6i FMN2-nitropropane dioxygenase / 0.820
3p8j FMNPentaerythritol tetranitrate reductase / 0.820
3p67 FMNPentaerythritol tetranitrate reductase / 0.819
3p82 FMNPentaerythritol tetranitrate reductase / 0.818
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.816
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.808
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.802
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.797
2j6x FMNLactate oxidase / 0.797
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.794
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.793
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.792
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.791
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.790
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.789
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.788
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.784
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.782
4jic FMNGTN Reductase / 0.782
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.779
3atz FMNProstaglandin F2a synthase / 0.778
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.775
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.774
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.774
2e77 FMNLactate oxidase / 0.771
4e2b FMNDehydrogenase / 0.769
4rje FNRLactate oxidase / 0.767
2du2 FMNLactate oxidase / 0.766
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.766
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.760
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.745
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.742
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.740
4cw5 FMNDfnA / 0.739
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.738
3b03 VNRIsopentenyl-diphosphate delta-isomerase / 0.735
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.735
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.725
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.718
3aty FMNProstaglandin F2a synthase / 0.712
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.711
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.704
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.703
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.698
3rpe FADPutative modulator of drug activity / 0.696
3gka FMNN-ethylmaleimide reductase / 0.688
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.687
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.686
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.684
2c12 FADNitroalkane oxidase 1.7.3.1 0.684
1t0i FMNNAD(P)H-dependent FMN reductase LOT6 / 0.681
1z44 FMNNADPH dehydrogenase / 0.676
3hf3 FMNChromate reductase / 0.675
2gjl FMNNitronate monooxygenase 1.13.12.16 0.673
3n14 FMNXenobiotic reductase / 0.672
1p4m FMNRiboflavin kinase 2.7.1.26 0.671
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.671
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.669
1szg FNSCytochrome b2, mitochondrial 1.1.2.3 0.668
3oix FMNDihydroorotate dehydrogenase / 0.665
3g5m FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.664
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.664
4m0c FMNFMN-dependent NADH-azoreductase 1 / 0.663
4zvn FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.663
5a8a FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.662
5ebu FMNLactate oxidase / 0.662
3qfr FMNNADPH--cytochrome P450 reductase / 0.660
2q9u FMNA-type flavoprotein / 0.657
4pyt FADUDP-N-acetylenolpyruvoylglucosamine reductase / 0.655
1yrx FMNAppA protein / 0.654
2dvl FADAcyl-CoA dehydrogenase / 0.653
2z9d FMNFMN-dependent NADH-azoreductase / 0.652
3esz FMNFlavodoxin / 0.652
3w77 FMNFMN-dependent NADH-azoreductase / 0.652
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.651
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.651
4z38 FMNMlnA / 0.650