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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pj3 NAD NAD-dependent malic enzyme, mitochondrial 1.1.1.38

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.106
1efl NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.027
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.026
1do8 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.024
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.881
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.869
1qr6 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.852
1gz4 ATPNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.773
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.746
1pj4 ATPNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.735
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.726
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.726
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.716
4c4o NADSADH / 0.712
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.710
1llq NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.710
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.701
3d64 NADAdenosylhomocysteinase / 0.699
3ing NDPHomoserine dehydrogenase related protein / 0.696
4oaq NDPR-specific carbonyl reductase / 0.696
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.695
1o0s NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.688
4k28 NADShikimate dehydrogenase family protein / 0.688
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.684
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.678
4z0p NDPNAD-dependent dehydrogenase / 0.674
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.672
1ky4 NADAdenosylhomocysteinase 3.3.1.1 0.671
4weq NAPNAD-dependent dehydrogenase / 0.669
5bsf NADPyrroline-5-carboxylate reductase / 0.669
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.668
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.668
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.668
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.667
2o4c NADErythronate-4-phosphate dehydrogenase / 0.666
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.665
4ebf NADPhosphonate dehydrogenase 1.20.1.1 0.664
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.664
2ph5 NADHomospermidine synthase / 0.663
3wv7 ADPHmd co-occurring protein HcgE / 0.663
5a03 NDPGlucose-fructose oxidoreductase / 0.663
2v7g NADUrocanate hydratase 4.2.1.49 0.662
4xgi NADGlutamate dehydrogenase / 0.662
3phi NDPShikimate dehydrogenase (NADP(+)) / 0.659
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.659
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.658
3t4e NADQuinate/shikimate dehydrogenase / 0.658
2rcy NAPPyrroline-5-carboxylate reductase / 0.656
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.654
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.653
3ec7 NADInositol 2-dehydrogenase / 0.653
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.652
2g5c NADPrephenate dehydrogenase / 0.651
4b7x NAPProbable oxidoreductase / 0.651
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.650