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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pj2 NAI NAD-dependent malic enzyme, mitochondrial 1.1.1.38

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.091
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 1.026
1do8 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.975
1efl NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.974
1qr6 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.856
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.851
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.824
1gz4 ATPNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.761
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.747
1pj4 ATPNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.743
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.742
1o0s NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.727
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.705
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.703
4c4o NADSADH / 0.701
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.694
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.693
4xgi NADGlutamate dehydrogenase / 0.692
3q2k NAIProbable oxidoreductase / 0.691
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.690
3tnl NADShikimate dehydrogenase (NADP(+)) / 0.689
5a05 NDPGlucose-fructose oxidoreductase / 0.683
4weq NAPNAD-dependent dehydrogenase / 0.675
3phi NDPShikimate dehydrogenase (NADP(+)) / 0.674
5a02 NAPGlucose-fructose oxidoreductase / 0.674
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.672
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.670
4oaq NDPR-specific carbonyl reductase / 0.668
5a03 NDPGlucose-fructose oxidoreductase / 0.667
4z0p NDPNAD-dependent dehydrogenase / 0.666
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.661
2ph5 NADHomospermidine synthase / 0.661
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.659
1llq NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.658
3d64 NADAdenosylhomocysteinase / 0.657
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.656
3mvq NDPGlutamate dehydrogenase 1, mitochondrial 1.4.1.3 0.656
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.654
1yon A2R2-dehydropantoate 2-reductase 1.1.1.169 0.653
4ros APRMalate dehydrogenase / 0.653
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.652
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 0.652
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.652
1pjc NADAlanine dehydrogenase / 0.651
1o6z NADMalate dehydrogenase / 0.650