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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pd8 CO4 Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1pd8 CO4Dihydrofolate reductase 1.5.1.3 1.017
1pd9 CO4Dihydrofolate reductase 1.5.1.3 0.836
4dph P65Bifunctional dihydrofolate reductase-thymidylate synthase / 0.728
1kms LIHDihydrofolate reductase 1.5.1.3 0.724
1s3v TQDDihydrofolate reductase 1.5.1.3 0.723
4m2x TMQDihydrofolate reductase 1.5.1.3 0.697
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.686
1hfr MOTDihydrofolate reductase 1.5.1.3 0.683
1hfp MOTDihydrofolate reductase 1.5.1.3 0.682
1u71 MXADihydrofolate reductase 1.5.1.3 0.665
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.660
1hfq MOTDihydrofolate reductase 1.5.1.3 0.655