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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1owk 303 Urokinase-type plasminogen activator 3.4.21.73

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1owk 303Urokinase-type plasminogen activator 3.4.21.73 0.951
1owd 497Urokinase-type plasminogen activator 3.4.21.73 0.806
1owe 675Urokinase-type plasminogen activator 3.4.21.73 0.781
1u6q 745Urokinase-type plasminogen activator 3.4.21.73 0.767
4fuf 8UPUrokinase-type plasminogen activator 3.4.21.73 0.767
4fuj 1U9Urokinase-type plasminogen activator 3.4.21.73 0.762
4fud 6UPUrokinase-type plasminogen activator 3.4.21.73 0.756
4e5i 0N9Polymerase acidic protein / 0.744
4fue 7UPUrokinase-type plasminogen activator 3.4.21.73 0.737
3v0x ANHCationic trypsin 3.4.21.4 0.731
1f92 UKPUrokinase-type plasminogen activator 3.4.21.73 0.729
4fub 4UPUrokinase-type plasminogen activator 3.4.21.73 0.728
1sqt UI3Urokinase-type plasminogen activator 3.4.21.73 0.723
1vja 7INUrokinase-type plasminogen activator 3.4.21.73 0.716
4e7r 0NWProthrombin 3.4.21.5 0.700
1ny2 ARG_PRO_PRO_GLYProthrombin 3.4.21.5 0.696
1wqv PSMCoagulation factor VII 3.4.21.21 0.693
4baq M4ZProthrombin 3.4.21.5 0.689
2zhq 27UProthrombin 3.4.21.5 0.679
1zsk 421Coagulation factor XI 3.4.21.27 0.677
2anm CDOProthrombin 3.4.21.5 0.677
2bok 784Coagulation factor X 3.4.21.6 0.673
2zhe 13UProthrombin 3.4.21.5 0.671
4ne0 ZZUHydroxylase / 0.669
1ghv 120Prothrombin 3.4.21.5 0.667
4djy 0KRBeta-secretase 1 3.4.23.46 0.662
1w13 SM1Urokinase-type plasminogen activator 3.4.21.73 0.661
4fui UI3Urokinase-type plasminogen activator 3.4.21.73 0.661
4e5f 0N7Polymerase acidic protein / 0.660
2viv VG2Urokinase-type plasminogen activator 3.4.21.73 0.658
2zg0 50UProthrombin 3.4.21.5 0.658
2zi2 24UProthrombin 3.4.21.5 0.657
3biu 10UProthrombin 3.4.21.5 0.657
4jpc 1M6Beta-secretase 1 3.4.23.46 0.656
2c4f GILCoagulation factor VII 3.4.21.21 0.654
3plp BBACationic trypsin 3.4.21.4 0.653
4azy 7F3Beta-secretase 1 3.4.23.46 0.653
4acx S8ZBeta-secretase 1 3.4.23.46 0.652
2zfq 45UProthrombin 3.4.21.5 0.651
1vaf ARRNitric oxide synthase, inducible 1.14.13.39 0.650
2znk 31UProthrombin 3.4.21.5 0.650