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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ohj COP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ohj COPDihydrofolate reductase 1.5.1.3 1.060
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.832
3eig MTXDihydrofolate reductase 1.5.1.3 0.814
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.810
1dls MTXDihydrofolate reductase 1.5.1.3 0.804
1df7 MTXDihydrofolate reductase 1.5.1.3 0.800
1dre MTXDihydrofolate reductase 1.5.1.3 0.799
1u72 MTXDihydrofolate reductase 1.5.1.3 0.799
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.791
1u70 MTXDihydrofolate reductase 1.5.1.3 0.789
2zza FOLDihydrofolate reductase / 0.787
1tdr MTXDihydrofolate reductase 1.5.1.3 0.779
3dfr MTXDihydrofolate reductase 1.5.1.3 0.776
3dau MTXDihydrofolate reductase 1.5.1.3 0.771
1hfp MOTDihydrofolate reductase 1.5.1.3 0.768
3och 2MXDihydrofolate reductase 1.5.1.3 0.767
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.766
4qi9 MTXDihydrofolate reductase / 0.765
2drc MTXDihydrofolate reductase 1.5.1.3 0.762
4kfj FOLDihydrofolate reductase 1.5.1.3 0.760
5hi6 MTXDihydrofolate reductase / 0.760
3drc MTXDihydrofolate reductase 1.5.1.3 0.753
4m6k FOLDihydrofolate reductase 1.5.1.3 0.751
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.746
1drf FOLDihydrofolate reductase 1.5.1.3 0.737
1dra MTXDihydrofolate reductase 1.5.1.3 0.734
1dyh DZFDihydrofolate reductase 1.5.1.3 0.732
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.732
1dhf FOLDihydrofolate reductase 1.5.1.3 0.731
3frd DHFDihydrofolate reductase 1.5.1.3 0.731
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.730
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.726
1ohk COPDihydrofolate reductase 1.5.1.3 0.725
4dfr MTXDihydrofolate reductase 1.5.1.3 0.724
4x5f FOLDihydrofolate reductase 1.5.1.3 0.724
4x5h FOLDihydrofolate reductase 1.5.1.3 0.724
4p66 MTXDihydrofolate reductase / 0.722
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.721
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.720
4i13 FOLDihydrofolate reductase 1.5.1.3 0.719
1re7 FOLDihydrofolate reductase 1.5.1.3 0.714
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.713
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.713
1e26 GPBDihydrofolate reductase 1.5.1.3 0.712
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.712
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.711
1jom FFODihydrofolate reductase 1.5.1.3 0.709
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.709
3tq9 MTXDihydrofolate reductase / 0.708
5ccc DDFDihydrofolate reductase 1.5.1.3 0.708
4i1n FOLDihydrofolate reductase 1.5.1.3 0.707
2dhf DZFDihydrofolate reductase 1.5.1.3 0.706
2w3m FOLDihydrofolate reductase 1.5.1.3 0.706
7dfr FOLDihydrofolate reductase 1.5.1.3 0.702
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.700
2d0k FOLDihydrofolate reductase 1.5.1.3 0.700
4fhb FOLDihydrofolate reductase 1.5.1.3 0.700
4keb FOLDihydrofolate reductase 1.5.1.3 0.699
4x5i FOLDihydrofolate reductase 1.5.1.3 0.699
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.697
3ghw GHWDihydrofolate reductase 1.5.1.3 0.695
4x5g FOLDihydrofolate reductase 1.5.1.3 0.695
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.694
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.694
3tqb FOLDihydrofolate reductase / 0.694
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.693
1hfr MOTDihydrofolate reductase 1.5.1.3 0.691
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.691
2qk8 MTXDihydrofolate reductase / 0.690
4p68 MTXDihydrofolate reductase / 0.687
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.686
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.685
3ghv GHCDihydrofolate reductase 1.5.1.3 0.683
1hfq MOTDihydrofolate reductase 1.5.1.3 0.681
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.681
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.681
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.678
4m6l 21VDihydrofolate reductase 1.5.1.3 0.675
1dhi MTXDihydrofolate reductase 1.5.1.3 0.674
1dyi FOLDihydrofolate reductase 1.5.1.3 0.671
2g1m 4HGEgl nine homolog 1 / 0.670
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.669
1drb MTXDihydrofolate reductase 1.5.1.3 0.668
1kmv LIIDihydrofolate reductase 1.5.1.3 0.666
4bqw QNMEgl nine homolog 1 / 0.666
4dp3 MMVBifunctional dihydrofolate reductase-thymidylate synthase / 0.666
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.665
3dat MTXDihydrofolate reductase / 0.663
3ia4 MTXDihydrofolate reductase / 0.662
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.653
1ddr MTXDihydrofolate reductase 1.5.1.3 0.652
4h95 06UDihydrofolate reductase 1.5.1.3 0.652
1aoe GW3Dihydrofolate reductase 1.5.1.3 0.650