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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1od1 0QS Endothiapepsin 3.4.23.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1od1 0QSEndothiapepsin 3.4.23.22 1.369
2jjj 0QSEndothiapepsin 3.4.23.22 1.293
2jji 0QSEndothiapepsin 3.4.23.22 1.212
1e82 M90Endothiapepsin 3.4.23.22 1.003
1gvt 2ZSEndothiapepsin 3.4.23.22 0.977
1e81 M91Endothiapepsin 3.4.23.22 0.965
1gvw 0EMEndothiapepsin 3.4.23.22 0.906
1e80 0GQEndothiapepsin 3.4.23.22 0.898
1ppl 1Z7Penicillopepsin-1 3.4.23.20 0.877
1bxo PP7Penicillopepsin-1 3.4.23.20 0.874
1gvv 0GMEndothiapepsin 3.4.23.22 0.874
1bxq PP8Penicillopepsin-1 3.4.23.20 0.865
1ppk IVVPenicillopepsin-1 3.4.23.20 0.848
1ppm 0P1Penicillopepsin-1 3.4.23.20 0.833
1rne C60Renin 3.4.23.15 0.807
1bil 0IURenin 3.4.23.15 0.779
1xe5 5FEPlasmepsin-2 3.4.23.39 0.770
1qrp HH0Pepsin A-4 3.4.23.1 0.769
3prs RITEndothiapepsin 3.4.23.22 0.767
1zap A70Candidapepsin-2 3.4.23.24 0.762
1psa 0ZLPepsin A 3.4.23.1 0.757
2f3e AXQBeta-secretase 1 3.4.23.46 0.757
1eag A70Candidapepsin-2 3.4.23.24 0.751
3d91 REMRenin 3.4.23.15 0.743
3pww ROCEndothiapepsin 3.4.23.22 0.741
3veu 0GOBeta-secretase 1 3.4.23.46 0.736
3k5g BJCBeta-secretase 1 3.4.23.46 0.724
1bim 0QBRenin 3.4.23.15 0.722
3dv5 BAVBeta-secretase 1 3.4.23.46 0.721
2g20 L1ARenin 3.4.23.15 0.720
2web PP4Penicillopepsin-1 3.4.23.20 0.717
2p83 MR0Beta-secretase 1 3.4.23.46 0.716
2wf2 ZY2Beta-secretase 1 3.4.23.46 0.712
3k5f AYHBeta-secretase 1 3.4.23.46 0.712
2f3f AXFBeta-secretase 1 3.4.23.46 0.706
2g94 ZPQBeta-secretase 1 3.4.23.46 0.703
3r2f PB0Beta-secretase 1 3.4.23.46 0.699
2b8v 3BNBeta-secretase 1 3.4.23.46 0.697
2hb3 GRLProtease / 0.688
3slz 3TLPutative gag-pro-pol polyprotein / 0.683
3own 3OXRenin 3.4.23.15 0.676
1hpv 478Gag-Pol polyprotein / 0.675
2hiz LIJBeta-secretase 1 3.4.23.46 0.674
4kb9 G79Protease / 0.670
2vj6 VG5Beta-secretase 1 3.4.23.46 0.668
3ohf 3HFBeta-secretase 1 3.4.23.46 0.668
1w6h TITPlasmepsin-2 3.4.23.39 0.664
3lpj Z75Beta-secretase 1 3.4.23.46 0.664
3o9f K2DGag-Pol polyprotein / 0.663
4exg 916Beta-secretase 1 3.4.23.46 0.663
4k9h 1QUBeta-secretase 1 3.4.23.46 0.663
2p8h MY9Beta-secretase 1 3.4.23.46 0.662
4ewo 996Beta-secretase 1 3.4.23.46 0.662
2hm1 LIQBeta-secretase 1 3.4.23.46 0.661
2viz VG4Beta-secretase 1 3.4.23.46 0.661
1t7i 017Gag-Pol polyprotein 3.4.23.16 0.659
3ixk 929Beta-secretase 1 3.4.23.46 0.659
4i0j 842Beta-secretase 1 3.4.23.46 0.659
3toh 079Gag-Pol polyprotein 2.7.7.49 0.656
2p3b 3TLV-1 PROTEASE protein / 0.655
2p3b 3TLV-1 protease / 0.655
3st5 G89Gag-Pol polyprotein 3.4.23.16 0.655
3vfa 031Gag-Pol polyprotein 3.4.23.16 0.653
4hdp G52Gag-Pol polyprotein 3.4.23.16 0.653
2vnm CM8Beta-secretase 1 3.4.23.46 0.652
2wed PP6Penicillopepsin-1 3.4.23.20 0.651
2i4v DJRV-1 protease / 0.650
3tl9 ROCGag-Pol polyprotein 3.4.23.16 0.650