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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1njc DCM Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1njc DCMThymidylate synthase / 0.957
1tsy UMPThymidylate synthase / 0.840
1tsv UMPThymidylate synthase / 0.831
1bp0 UMPThymidylate synthase / 0.826
1bid UMPThymidylate synthase / 0.823
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.814
2vet UMPThymidylate synthase / 0.809
1vzb UMPThymidylate synthase / 0.807
1njd UMPThymidylate synthase / 0.803
2tdm UMPThymidylate synthase / 0.800
1tsx UMPThymidylate synthase / 0.799
1nja DCMThymidylate synthase / 0.796
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.791
1bp6 UMPThymidylate synthase / 0.776
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.775
1jmf UMPThymidylate synthase / 0.766
5by6 UMPThymidylate synthase / 0.761
1vza UMPThymidylate synthase / 0.760
1jmh UMPThymidylate synthase / 0.758
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.744
1f28 UMPThymidylate synthase 2.1.1.45 0.742
2g86 UMPThymidylate synthase / 0.740
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.738
1nje DCMThymidylate synthase / 0.738
1jmi UMPThymidylate synthase / 0.732
4irr UMPThymidylate synthase / 0.723
2fto TMPThymidylate synthase / 0.722
1bpj UMPThymidylate synthase / 0.720
2g8a UMPThymidylate synthase / 0.717
2g89 UMPThymidylate synthase / 0.716
4dq1 UMPThymidylate synthase / 0.709
4psg NOHThymidylate synthase / 0.708
1tdu DURThymidylate synthase / 0.703
1tdc UMPThymidylate synthase / 0.701
1njb UMPThymidylate synthase / 0.700
3qj7 UMPThymidylate synthase ThyA / 0.700
4iqq UMPThymidylate synthase / 0.691
2g8d UMPThymidylate synthase / 0.687
1thy UMPThymidylate synthase / 0.683
4xsd UMPThymidylate synthase 2.1.1.45 0.682
1tys TMPThymidylate synthase / 0.677
1jmg UMPThymidylate synthase / 0.671
4fox UMPThymidylate synthase ThyA / 0.671
4h0u UMPThymidylate synthase / 0.665
2tsr UMPThymidylate synthase 2.1.1.45 0.650