Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ngs TPP Transketolase 1 2.2.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ngs TPPTransketolase 1 2.2.1.1 1.127
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.964
3upt TPPTransketolase / 0.961
1tkb N1TTransketolase 1 2.2.1.1 0.941
1ay0 TPPTransketolase 1 2.2.1.1 0.935
3m7i TPPTransketolase / 0.914
2r5n TPPTransketolase 1 / 0.896
3m34 TPPTransketolase / 0.893
1tkc M6TTransketolase 1 2.2.1.1 0.885
2r8p T6FTransketolase 1 / 0.870
3m6l TPPTransketolase / 0.867
1trk TPPTransketolase 1 2.2.1.1 0.865
1gpu THDTransketolase 1 2.2.1.1 0.862
2r8o T5XTransketolase 1 / 0.842
1tka N3TTransketolase 1 2.2.1.1 0.809
3rim TPPTransketolase 2.2.1.1 0.768
4c7x TPPTransketolase / 0.751
3lq4 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.741
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.736
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.735
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.735
3dv0 TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.715
3dv0 TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.715
4qel TZDBenzoylformate decarboxylase 4.1.1.7 0.713
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 0.712
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.711
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.710
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.710
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.709
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.706
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.703
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.701
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 0.699
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.698
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 0.698
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.694
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 0.693
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.691
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.691
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.691
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.691
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.690
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.688
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 0.688
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 0.685
3dva TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.684
3dva TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.684
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 0.684
1y9d TPPPyruvate oxidase 1.2.3.3 0.683
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.683
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.682
4juf TPPBenzoylformate decarboxylase 4.1.1.7 0.681
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.680
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.680
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.680
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 0.675
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.675
2qtc TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.673
2uz1 TPPBenzaldehyde lyase / 0.673
4jub TPPBenzoylformate decarboxylase 4.1.1.7 0.673
3ahe THDProbable phosphoketolase / 0.672
5ahk TPPAcetolactate synthase II, large subunit / 0.671
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.671
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.669
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.669
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.669
3ahj TPPProbable phosphoketolase / 0.666
3zht TD9Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.666
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.666
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.663
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.663
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.663
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.663
2ezt TDMPyruvate oxidase 1.2.3.3 0.661
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.661
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.659
3eya TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.657
2ji7 OXTOxalyl-CoA decarboxylase 4.1.1.8 0.656
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.654
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.654
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.653
1pox TPPPyruvate oxidase 1.2.3.3 0.651
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.651
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.651