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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1mvs DTM Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1mvs DTMDihydrofolate reductase 1.5.1.3 0.994
1mvt DTMDihydrofolate reductase 1.5.1.3 0.812
1ly3 COGDihydrofolate reductase 1.5.1.3 0.680
3td8 D2RDihydrofolate reductase 1.5.1.3 0.668
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.665
1s3v TQDDihydrofolate reductase 1.5.1.3 0.663
1hfr MOTDihydrofolate reductase 1.5.1.3 0.660
1pd9 CO4Dihydrofolate reductase 1.5.1.3 0.657
1dds MTXDihydrofolate reductase 1.5.1.3 0.655
3jsu KA5Bifunctional dihydrofolate reductase-thymidylate synthase / 0.653