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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1mlz PLP Adenosylmethionine-8-amino-7-oxononanoate aminotransferase 2.6.1.62

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1mlz PLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase 2.6.1.62 0.943
3tfu PL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase 2.6.1.62 0.847
4aoa IK2Beta-phenylalanine transaminase 2.6.1 0.798
4ba5 PXGProbable aminotransferase / 0.761
4zwm PLPOrnithine aminotransferase, mitochondrial, putative / 0.748
4ao4 PLKBeta-transaminase / 0.740
2ykv IK2Beta-transaminase / 0.736
2hp2 KE4Glutamate-1-semialdehyde 2,1-aminomutase 5.4.3.8 0.734
1wkh PPE[LysW]-aminoadipate semialdehyde transaminase / 0.720
4jey PLPAcetylornithine/succinyldiaminopimelate aminotransferase 2.6.1.11 0.713
2pb2 PLPAcetylornithine/succinyldiaminopimelate aminotransferase 2.6.1.11 0.706
4zm3 PLPAminotransferase / 0.706
5k8b PDG8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase / 0.699
1b9i PXG3-amino-5-hydroxybenzoate synthase 4.2.1.144 0.678
4jf1 PLPAcetylornithine/succinyldiaminopimelate aminotransferase 2.6.1.11 0.676
4adc PLPSuccinylornithine transaminase 2.6.1.81 0.666
4eb7 PLPCysteine desulfurase IscS 2 / 0.665
2bwp PLG5-aminolevulinate synthase 2.3.1.37 0.663
2oat PFMOrnithine aminotransferase, mitochondrial 2.6.1.13 0.659
5cvc PLPSerine racemase / 0.651