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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1m79 MQ1 Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1m79 MQ1Dihydrofolate reductase 1.5.1.3 0.953
1ia2 TQ4Dihydrofolate reductase 1.5.1.3 0.864
1ia1 TQ3Dihydrofolate reductase 1.5.1.3 0.819
1m7a MQUDihydrofolate reductase 1.5.1.3 0.737
1ia3 TQ5Dihydrofolate reductase 1.5.1.3 0.732
3qlw N22Dihydrofolate reductase 1.5.1.3 0.706
3qls 55VDihydrofolate reductase 1.5.1.3 0.673
1ia4 TQ6Dihydrofolate reductase 1.5.1.3 0.665
2blb CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.659
3sr5 Q12Dihydrofolate reductase 1.5.1.3 0.658
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.653
3k47 D09Dihydrofolate reductase 1.5.1.3 0.652
4xt8 TMQPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.650