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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1kdm DHT Sex hormone-binding globulin

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1kdm DHTSex hormone-binding globulin / 1.113
1kdk DHTSex hormone-binding globulin / 0.998
1d2s DHTSex hormone-binding globulin / 0.952
1f5f DHTSex hormone-binding globulin / 0.890
1lhv NOGSex hormone-binding globulin / 0.811
1lhn AONSex hormone-binding globulin / 0.805
2pnu ENMAndrogen receptor / 0.740
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.740
1t7f DHTAndrogen receptor / 0.727
2ylo TESAndrogen receptor / 0.727
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.725
2mm3 CHOGastrotropin / 0.721
3dey DHTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.721
3klm DHTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.721
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.710
1ya3 STRMineralocorticoid receptor / 0.710
4at2 ASDPossible succinate dehydrogenase / 0.708
3gkj HC3Niemann-Pick C1 protein / 0.707
5hyr ESTEstrogen receptor / 0.706
1lho AOMSex hormone-binding globulin / 0.701
3cmf PDN3-oxo-5-beta-steroid 4-dehydrogenase / 0.700
3zqt TESAndrogen receptor / 0.697
4nky 3QZSteroid 17-alpha-hydroxylase/17,20 lyase / 0.697
2j7x ESTEstrogen receptor beta / 0.696
4jbt ASDCytochrome P450 monooxygenase / 0.696
5l7d CLRSmoothened homolog / 0.689
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.688
3s79 ASDAromatase 1.14.14.14 0.688
3eqm ASDAromatase 1.14.14.14 0.684
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.681
2aa6 STRMineralocorticoid receptor / 0.681
1fdt ESTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.678
5hgc HCYUncharacterized protein / 0.678
3gyt DL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily / 0.672
2abi 1CAMineralocorticoid receptor / 0.670
1lnm DTXBilin-binding protein / 0.667
3cav CI23-oxo-5-beta-steroid 4-dehydrogenase / 0.667
1lke DOGBilin-binding protein / 0.666
3mnp DEXGlucocorticoid receptor / 0.666
1h60 STRPentaerythritol tetranitrate reductase / 0.665
2ft9 CHDFatty acid-binding protein 2, liver / 0.665
4ple CPSNuclear receptor subfamily 5 group A member 2 / 0.665
3w1w CHDFerrochelatase, mitochondrial 4.99.1.1 0.664
1o1v TCHGastrotropin / 0.663
1fds ESTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.655
3mne DEXGlucocorticoid receptor / 0.655
4q0a 4OAVitamin D3 receptor A / 0.655
2ocf ESTEstrogen receptor / 0.651