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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ia4 TQ6 Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ia4 TQ6Dihydrofolate reductase 1.5.1.3 1.008
1ia3 TQ5Dihydrofolate reductase 1.5.1.3 0.890
1m78 CLZDihydrofolate reductase 1.5.1.3 0.767
1ia1 TQ3Dihydrofolate reductase 1.5.1.3 0.709
1aoe GW3Dihydrofolate reductase 1.5.1.3 0.689
1kms LIHDihydrofolate reductase 1.5.1.3 0.666
1m79 MQ1Dihydrofolate reductase 1.5.1.3 0.665
1m7a MQUDihydrofolate reductase 1.5.1.3 0.658
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.658
3qls 55VDihydrofolate reductase 1.5.1.3 0.656
3eko PYUHeat shock protein HSP 90-alpha / 0.655
3qyo Q24Dihydrofolate reductase 1.5.1.3 0.653