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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ia2 TQ4 Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ia2 TQ4Dihydrofolate reductase 1.5.1.3 1.013
1m79 MQ1Dihydrofolate reductase 1.5.1.3 0.864
1ia1 TQ3Dihydrofolate reductase 1.5.1.3 0.753
1dlr MXADihydrofolate reductase 1.5.1.3 0.703
3um5 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.698
1m78 CLZDihydrofolate reductase 1.5.1.3 0.687
1j3j CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.671
1ia3 TQ5Dihydrofolate reductase 1.5.1.3 0.668
2blb CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.668
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.665
1m7a MQUDihydrofolate reductase 1.5.1.3 0.664
2bla CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.662