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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1hwl ADP 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.1.1.34

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1hwl ADP3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.1.1.34 0.883
3hpr AP5Adenylate kinase / 0.672
4ehy ADPTetraacyldisaccharide 4'-kinase / 0.669
2puc GUNHTH-type transcriptional repressor PurR / 0.666
2opn SUFFarnesyl pyrophosphate synthase 2.5.1.10 0.656
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.655
1dq9 HMG3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.1.1.34 0.651