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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ex7 5GP Guanylate kinase 2.7.4.8

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ex7 5GPGuanylate kinase 2.7.4.8 0.966
1gky 5GPGuanylate kinase 2.7.4.8 0.946
1lvg 5GPGuanylate kinase 2.7.4.8 0.848
3lnc 5GPGuanylate kinase / 0.815
2anb 5GPGuanylate kinase 2.7.4.8 0.812
2j41 5GPGuanylate kinase / 0.803
3tr0 5GPGuanylate kinase / 0.754
2f3r G5PGuanylate kinase 2.7.4.8 0.693
2an9 GDPGuanylate kinase 2.7.4.8 0.682
1qiq ACCIsopenicillin N synthase 1.21.3.1 0.660
1w06 W05Isopenicillin N synthase 1.21.3.1 0.660
1bk0 ACVIsopenicillin N synthase 1.21.3.1 0.658
2ivf MGDAlpha-subunit of ethylbenzene dehydrogenase / 0.658
4ajj 88RL-lactate dehydrogenase A chain 1.1.1.27 0.655
2y60 M8FIsopenicillin N synthase 1.21.3.1 0.652
4x5h FOLDihydrofolate reductase 1.5.1.3 0.651