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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1e26 GPB Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1e26 GPBDihydrofolate reductase 1.5.1.3 1.085
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.797
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.796
1hfr MOTDihydrofolate reductase 1.5.1.3 0.785
1dls MTXDihydrofolate reductase 1.5.1.3 0.780
1hfq MOTDihydrofolate reductase 1.5.1.3 0.778
3ia4 MTXDihydrofolate reductase / 0.778
5hi6 MTXDihydrofolate reductase / 0.777
4p66 MTXDihydrofolate reductase / 0.776
3drc MTXDihydrofolate reductase 1.5.1.3 0.774
1hfp MOTDihydrofolate reductase 1.5.1.3 0.773
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.770
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.767
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.767
1u70 MTXDihydrofolate reductase 1.5.1.3 0.767
2drc MTXDihydrofolate reductase 1.5.1.3 0.766
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.763
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.762
2qk8 MTXDihydrofolate reductase / 0.760
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.759
3dau MTXDihydrofolate reductase 1.5.1.3 0.757
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.755
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.754
4dfr MTXDihydrofolate reductase 1.5.1.3 0.752
1df7 MTXDihydrofolate reductase 1.5.1.3 0.750
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.750
3tq9 MTXDihydrofolate reductase / 0.749
1dra MTXDihydrofolate reductase 1.5.1.3 0.747
2zza FOLDihydrofolate reductase / 0.746
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.746
1re7 FOLDihydrofolate reductase 1.5.1.3 0.740
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.739
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.737
4m6k FOLDihydrofolate reductase 1.5.1.3 0.737
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.736
4x5h FOLDihydrofolate reductase 1.5.1.3 0.736
7dfr FOLDihydrofolate reductase 1.5.1.3 0.736
1dyi FOLDihydrofolate reductase 1.5.1.3 0.734
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.733
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.732
3och 2MXDihydrofolate reductase 1.5.1.3 0.732
4p68 MTXDihydrofolate reductase / 0.730
4qi9 MTXDihydrofolate reductase / 0.729
1dre MTXDihydrofolate reductase 1.5.1.3 0.728
3dfr MTXDihydrofolate reductase 1.5.1.3 0.728
4x5i FOLDihydrofolate reductase 1.5.1.3 0.721
3tqb FOLDihydrofolate reductase / 0.720
3ghv GHCDihydrofolate reductase 1.5.1.3 0.719
1dhj MTXDihydrofolate reductase 1.5.1.3 0.717
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.717
2d0k FOLDihydrofolate reductase 1.5.1.3 0.716
1daj MOTDihydrofolate reductase 1.5.1.3 0.714
1tdr MTXDihydrofolate reductase 1.5.1.3 0.713
3eig MTXDihydrofolate reductase 1.5.1.3 0.713
4x5g FOLDihydrofolate reductase 1.5.1.3 0.713
1ohj COPDihydrofolate reductase 1.5.1.3 0.712
1jom FFODihydrofolate reductase 1.5.1.3 0.710
3dat MTXDihydrofolate reductase / 0.709
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.709
1drb MTXDihydrofolate reductase 1.5.1.3 0.706
2w3m FOLDihydrofolate reductase 1.5.1.3 0.704
1dyj DDFDihydrofolate reductase 1.5.1.3 0.703
1u72 MTXDihydrofolate reductase 1.5.1.3 0.703
4i1n FOLDihydrofolate reductase 1.5.1.3 0.703
1dhf FOLDihydrofolate reductase 1.5.1.3 0.702
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.698
4i13 FOLDihydrofolate reductase 1.5.1.3 0.696
4kfj FOLDihydrofolate reductase 1.5.1.3 0.696
3zku HCVIsopenicillin N synthase 1.21.3.1 0.694
1dhi MTXDihydrofolate reductase 1.5.1.3 0.692
3ghw GHWDihydrofolate reductase 1.5.1.3 0.690
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.685
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.683
4fhb FOLDihydrofolate reductase 1.5.1.3 0.683
1drf FOLDihydrofolate reductase 1.5.1.3 0.682
1dyh DZFDihydrofolate reductase 1.5.1.3 0.680
4m6l 21VDihydrofolate reductase 1.5.1.3 0.676
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.670
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.670
4bb3 KKAIsopenicillin N synthase 1.21.3.1 0.670
3frd DHFDihydrofolate reductase 1.5.1.3 0.669
4keb FOLDihydrofolate reductase 1.5.1.3 0.667
1jol FFODihydrofolate reductase 1.5.1.3 0.665
4ixf IXFDihydrofolate reductase 1.5.1.3 0.665
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.662
4bqy FNTEgl nine homolog 1 / 0.662
3lnc 5GPGuanylate kinase / 0.658
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.658
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.658
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.655
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.655
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.655
3jsu KA5Bifunctional dihydrofolate reductase-thymidylate synthase / 0.653
3jwm 5WBDihydrofolate reductase / 0.653
3mvw BHZNickel-binding periplasmic protein / 0.652
1x28 PGUAspartate aminotransferase 2.6.1.1 0.651
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.651