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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1drf FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1drf FOLDihydrofolate reductase 1.5.1.3 1.018
4kfj FOLDihydrofolate reductase 1.5.1.3 0.833
4m6k FOLDihydrofolate reductase 1.5.1.3 0.829
2zza FOLDihydrofolate reductase / 0.820
1dls MTXDihydrofolate reductase 1.5.1.3 0.805
2w3m FOLDihydrofolate reductase 1.5.1.3 0.805
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.801
4x5h FOLDihydrofolate reductase 1.5.1.3 0.801
4i13 FOLDihydrofolate reductase 1.5.1.3 0.799
4keb FOLDihydrofolate reductase 1.5.1.3 0.797
1dyi FOLDihydrofolate reductase 1.5.1.3 0.793
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.789
4i1n FOLDihydrofolate reductase 1.5.1.3 0.789
4x5i FOLDihydrofolate reductase 1.5.1.3 0.789
1dhf FOLDihydrofolate reductase 1.5.1.3 0.788
3tqb FOLDihydrofolate reductase / 0.786
4x5f FOLDihydrofolate reductase 1.5.1.3 0.781
4fhb FOLDihydrofolate reductase 1.5.1.3 0.779
3dau MTXDihydrofolate reductase 1.5.1.3 0.777
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.774
1hfq MOTDihydrofolate reductase 1.5.1.3 0.773
1dyh DZFDihydrofolate reductase 1.5.1.3 0.772
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.769
4x5g FOLDihydrofolate reductase 1.5.1.3 0.769
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.768
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.768
2d0k FOLDihydrofolate reductase 1.5.1.3 0.766
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.766
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.763
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.761
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.761
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.760
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.755
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.755
3ghw GHWDihydrofolate reductase 1.5.1.3 0.755
1tdr MTXDihydrofolate reductase 1.5.1.3 0.751
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.750
3eig MTXDihydrofolate reductase 1.5.1.3 0.748
3ia4 MTXDihydrofolate reductase / 0.746
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.744
4dfr MTXDihydrofolate reductase 1.5.1.3 0.744
1hfr MOTDihydrofolate reductase 1.5.1.3 0.743
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.743
2dhf DZFDihydrofolate reductase 1.5.1.3 0.739
1ohk COPDihydrofolate reductase 1.5.1.3 0.738
1ohj COPDihydrofolate reductase 1.5.1.3 0.737
3frd DHFDihydrofolate reductase 1.5.1.3 0.735
1drb MTXDihydrofolate reductase 1.5.1.3 0.734
3drc MTXDihydrofolate reductase 1.5.1.3 0.733
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.732
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.731
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.730
3dfr MTXDihydrofolate reductase 1.5.1.3 0.728
1df7 MTXDihydrofolate reductase 1.5.1.3 0.724
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.724
1u72 MTXDihydrofolate reductase 1.5.1.3 0.723
1dre MTXDihydrofolate reductase 1.5.1.3 0.722
1re7 FOLDihydrofolate reductase 1.5.1.3 0.722
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.719
2drc MTXDihydrofolate reductase 1.5.1.3 0.719
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.718
3tq9 MTXDihydrofolate reductase / 0.714
1dra MTXDihydrofolate reductase 1.5.1.3 0.713
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.713
4kjj FOLDihydrofolate reductase 1.5.1.3 0.711
4m6l 21VDihydrofolate reductase 1.5.1.3 0.711
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.706
1u70 MTXDihydrofolate reductase 1.5.1.3 0.703
3och 2MXDihydrofolate reductase 1.5.1.3 0.700
1hfp MOTDihydrofolate reductase 1.5.1.3 0.697
4qi9 MTXDihydrofolate reductase / 0.697
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.696
1dyj DDFDihydrofolate reductase 1.5.1.3 0.693
2qk8 MTXDihydrofolate reductase / 0.692
7dfr FOLDihydrofolate reductase 1.5.1.3 0.691
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.685
1dhj MTXDihydrofolate reductase 1.5.1.3 0.684
1jom FFODihydrofolate reductase 1.5.1.3 0.683
1e26 GPBDihydrofolate reductase 1.5.1.3 0.682
4p66 MTXDihydrofolate reductase / 0.680
5hi6 MTXDihydrofolate reductase / 0.680
1jol FFODihydrofolate reductase 1.5.1.3 0.679
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.675
4p68 MTXDihydrofolate reductase / 0.670
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.668
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.665
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.663
4kdr SAHUbiquinone biosynthesis O-methyltransferase / 0.663
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.661
1dhi MTXDihydrofolate reductase 1.5.1.3 0.661
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.656
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.655
4eil FOLBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.653
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.653
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.652
3ghv GHCDihydrofolate reductase 1.5.1.3 0.652