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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1df7 MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1df7 MTXDihydrofolate reductase 1.5.1.3 1.100
3och 2MXDihydrofolate reductase 1.5.1.3 0.923
3drc MTXDihydrofolate reductase 1.5.1.3 0.922
3dau MTXDihydrofolate reductase 1.5.1.3 0.908
4p66 MTXDihydrofolate reductase / 0.906
2drc MTXDihydrofolate reductase 1.5.1.3 0.903
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.895
4dfr MTXDihydrofolate reductase 1.5.1.3 0.878
1dra MTXDihydrofolate reductase 1.5.1.3 0.875
5hi6 MTXDihydrofolate reductase / 0.875
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.872
3ia4 MTXDihydrofolate reductase / 0.867
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.855
1dhi MTXDihydrofolate reductase 1.5.1.3 0.841
3tq9 MTXDihydrofolate reductase / 0.833
1dls MTXDihydrofolate reductase 1.5.1.3 0.832
1drb MTXDihydrofolate reductase 1.5.1.3 0.828
1dre MTXDihydrofolate reductase 1.5.1.3 0.828
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.822
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.822
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.821
3dfr MTXDihydrofolate reductase 1.5.1.3 0.821
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.820
1tdr MTXDihydrofolate reductase 1.5.1.3 0.817
1u70 MTXDihydrofolate reductase 1.5.1.3 0.814
2qk8 MTXDihydrofolate reductase / 0.807
1ohj COPDihydrofolate reductase 1.5.1.3 0.800
3eig MTXDihydrofolate reductase 1.5.1.3 0.798
4qi9 MTXDihydrofolate reductase / 0.790
1jol FFODihydrofolate reductase 1.5.1.3 0.787
3frd DHFDihydrofolate reductase 1.5.1.3 0.776
4p68 MTXDihydrofolate reductase / 0.776
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.774
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.767
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.764
1dhj MTXDihydrofolate reductase 1.5.1.3 0.763
4x5i FOLDihydrofolate reductase 1.5.1.3 0.762
1dyj DDFDihydrofolate reductase 1.5.1.3 0.759
4i13 FOLDihydrofolate reductase 1.5.1.3 0.757
1jom FFODihydrofolate reductase 1.5.1.3 0.754
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.754
1dyi FOLDihydrofolate reductase 1.5.1.3 0.753
1dyh DZFDihydrofolate reductase 1.5.1.3 0.751
1hfr MOTDihydrofolate reductase 1.5.1.3 0.751
1e26 GPBDihydrofolate reductase 1.5.1.3 0.750
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.750
1u72 MTXDihydrofolate reductase 1.5.1.3 0.747
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.742
4i1n FOLDihydrofolate reductase 1.5.1.3 0.742
4x5f FOLDihydrofolate reductase 1.5.1.3 0.738
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.737
4m6k FOLDihydrofolate reductase 1.5.1.3 0.736
3dat MTXDihydrofolate reductase / 0.730
4kfj FOLDihydrofolate reductase 1.5.1.3 0.730
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.728
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.727
7dfr FOLDihydrofolate reductase 1.5.1.3 0.726
1drf FOLDihydrofolate reductase 1.5.1.3 0.724
4x5g FOLDihydrofolate reductase 1.5.1.3 0.723
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.722
4keb FOLDihydrofolate reductase 1.5.1.3 0.722
1hfp MOTDihydrofolate reductase 1.5.1.3 0.721
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.721
2dhf DZFDihydrofolate reductase 1.5.1.3 0.719
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.718
2d0k FOLDihydrofolate reductase 1.5.1.3 0.717
1dds MTXDihydrofolate reductase 1.5.1.3 0.714
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.714
2zza FOLDihydrofolate reductase / 0.714
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.714
2w3m FOLDihydrofolate reductase 1.5.1.3 0.713
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.709
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.709
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.708
4x5h FOLDihydrofolate reductase 1.5.1.3 0.704
4kjj FOLDihydrofolate reductase 1.5.1.3 0.702
5ccc DDFDihydrofolate reductase 1.5.1.3 0.701
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.699
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.698
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.698
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.698
4fhb FOLDihydrofolate reductase 1.5.1.3 0.698
1ohk COPDihydrofolate reductase 1.5.1.3 0.697
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.696
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.693
4m6l 21VDihydrofolate reductase 1.5.1.3 0.693
1hfq MOTDihydrofolate reductase 1.5.1.3 0.692
4bqs K2QShikimate kinase 2.7.1.71 0.679
3td8 D2RDihydrofolate reductase 1.5.1.3 0.678
1hbn TP7Methyl-coenzyme M reductase I subunit alpha 2.8.4.1 0.672
1hbn TP7Methyl-coenzyme M reductase I subunit beta 2.8.4.1 0.672
1dhf FOLDihydrofolate reductase 1.5.1.3 0.666
1w06 W05Isopenicillin N synthase 1.21.3.1 0.666
4bqy FNTEgl nine homolog 1 / 0.666
3ghw GHWDihydrofolate reductase 1.5.1.3 0.664
3tqb FOLDihydrofolate reductase / 0.663
1ndc TYDNucleoside diphosphate kinase, cytosolic 2.7.4.6 0.661
3kjs DQ1Bifunctional dihydrofolate reductase-thymidylate synthase / 0.660
3kkz SAMUncharacterized protein / 0.659
1daj MOTDihydrofolate reductase 1.5.1.3 0.657
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.655
2vbp VB1Isopenicillin N synthase 1.21.3.1 0.654
1jmg UMPThymidylate synthase / 0.652