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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ddu DDU Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ddu DDUThymidylate synthase / 0.848
1tdu DURThymidylate synthase / 0.772
4isk UMPThymidylate synthase / 0.757
4e5o UMPThymidylate synthase 2.1.1.45 0.740
1bdu DURThymidylate synthase / 0.739
2vet UMPThymidylate synthase / 0.736
1bid UMPThymidylate synthase / 0.731
1bp0 UMPThymidylate synthase / 0.725
1tsy UMPThymidylate synthase / 0.724
4h0u UMPThymidylate synthase / 0.722
4eb4 UMPThymidylate synthase 2.1.1.45 0.721
4dq1 UMPThymidylate synthase / 0.714
1njd UMPThymidylate synthase / 0.709
2fto TMPThymidylate synthase / 0.708
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.707
1bp6 UMPThymidylate synthase / 0.706
1vzb UMPThymidylate synthase / 0.704
2tdm UMPThymidylate synthase / 0.703
1tsv UMPThymidylate synthase / 0.702
1nja DCMThymidylate synthase / 0.701
1bpj UMPThymidylate synthase / 0.695
1f28 UMPThymidylate synthase 2.1.1.45 0.693
3bgx TMPThymidylate synthase / 0.692
1tsx UMPThymidylate synthase / 0.690
1jmi UMPThymidylate synthase / 0.685
2g8a UMPThymidylate synthase / 0.685
1njb UMPThymidylate synthase / 0.683
4iqq UMPThymidylate synthase / 0.682
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.679
4fox UMPThymidylate synthase ThyA / 0.678
1vza UMPThymidylate synthase / 0.677
1jmh UMPThymidylate synthase / 0.670
3qj7 UMPThymidylate synthase ThyA / 0.665
2g89 UMPThymidylate synthase / 0.660
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.654