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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dds MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dds MTXDihydrofolate reductase 1.5.1.3 1.027
4p66 MTXDihydrofolate reductase / 0.776
2drc MTXDihydrofolate reductase 1.5.1.3 0.774
4dfr MTXDihydrofolate reductase 1.5.1.3 0.760
5hi6 MTXDihydrofolate reductase / 0.752
1dhj MTXDihydrofolate reductase 1.5.1.3 0.743
3drc MTXDihydrofolate reductase 1.5.1.3 0.742
4qi9 MTXDihydrofolate reductase / 0.737
1hfr MOTDihydrofolate reductase 1.5.1.3 0.732
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.726
3dau MTXDihydrofolate reductase 1.5.1.3 0.721
1u70 MTXDihydrofolate reductase 1.5.1.3 0.720
3och 2MXDihydrofolate reductase 1.5.1.3 0.720
1df7 MTXDihydrofolate reductase 1.5.1.3 0.714
1u72 MTXDihydrofolate reductase 1.5.1.3 0.708
1tdr MTXDihydrofolate reductase 1.5.1.3 0.707
3dfr MTXDihydrofolate reductase 1.5.1.3 0.706
1ddr MTXDihydrofolate reductase 1.5.1.3 0.703
1dyi FOLDihydrofolate reductase 1.5.1.3 0.701
3eig MTXDihydrofolate reductase 1.5.1.3 0.701
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.700
3ia4 MTXDihydrofolate reductase / 0.697
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.695
3dat MTXDihydrofolate reductase / 0.693
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.685
1dls MTXDihydrofolate reductase 1.5.1.3 0.683
1dra MTXDihydrofolate reductase 1.5.1.3 0.683
4x5f FOLDihydrofolate reductase 1.5.1.3 0.682
1dhi MTXDihydrofolate reductase 1.5.1.3 0.679
7dfr FOLDihydrofolate reductase 1.5.1.3 0.677
4p68 MTXDihydrofolate reductase / 0.676
1dyh DZFDihydrofolate reductase 1.5.1.3 0.673
3i8a N22Dihydrofolate reductase 1.5.1.3 0.673
1hfq MOTDihydrofolate reductase 1.5.1.3 0.670
1s3w TQTDihydrofolate reductase 1.5.1.3 0.670
4x5g FOLDihydrofolate reductase 1.5.1.3 0.669
3frd DHFDihydrofolate reductase 1.5.1.3 0.666
1dre MTXDihydrofolate reductase 1.5.1.3 0.665
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.663
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.661
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.660
1dyj DDFDihydrofolate reductase 1.5.1.3 0.657
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.657
4keb FOLDihydrofolate reductase 1.5.1.3 0.657
2d0k FOLDihydrofolate reductase 1.5.1.3 0.656
1mvs DTMDihydrofolate reductase 1.5.1.3 0.655
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.655
4m6k FOLDihydrofolate reductase 1.5.1.3 0.655
2zza FOLDihydrofolate reductase / 0.653
1jom FFODihydrofolate reductase 1.5.1.3 0.652
4dph P65Bifunctional dihydrofolate reductase-thymidylate synthase / 0.652
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.651
3kjs DQ1Bifunctional dihydrofolate reductase-thymidylate synthase / 0.650