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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1cl2 PPG Cystathionine beta-lyase MetC 4.4.1.8

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1cl2 PPGCystathionine beta-lyase MetC 4.4.1.8 1.236
4itx IN5Cystathionine beta-lyase MetC 4.4.1.8 1.008
2gqn BLPCystathionine beta-lyase MetC 4.4.1.8 0.944
2fq6 P3FCystathionine beta-lyase MetC 4.4.1.8 0.921
1akb PPDAspartate aminotransferase, mitochondrial 2.6.1.1 0.782
1map KETAspartate aminotransferase, mitochondrial 2.6.1.1 0.773
1ivr CBAAspartate aminotransferase, mitochondrial 2.6.1.1 0.771
1arg PPDAspartate aminotransferase 2.6.1.1 0.764
2ycn P61Tyrosine phenol-lyase 4.1.99.2 0.746
1akc PPEAspartate aminotransferase, mitochondrial 2.6.1.1 0.744
1ahg TYR_PLPAspartate aminotransferase 2.6.1.1 0.728
1cq7 PY5Aspartate aminotransferase 2.6.1.1 0.706
3aej AA5Methionine gamma-lyase / 0.706
1arh PPDAspartate aminotransferase 2.6.1.1 0.700
1cq8 PY6Aspartate aminotransferase 2.6.1.1 0.699
1x28 PGUAspartate aminotransferase 2.6.1.1 0.697
1cq6 PY4Aspartate aminotransferase 2.6.1.1 0.696
3qpg 3QPAspartate aminotransferase 2.6.1.1 0.696
1maq PGUAspartate aminotransferase, mitochondrial 2.6.1.1 0.689
1wkh PPE[LysW]-aminoadipate semialdehyde transaminase / 0.688
4d96 5PAD-cysteine desulfhydrase / 0.681
4zwm PLPOrnithine aminotransferase, mitochondrial, putative / 0.677
3ei8 PL5LL-diaminopimelate aminotransferase, chloroplastic / 0.673
2bwp PLG5-aminolevulinate synthase 2.3.1.37 0.672
4adc PLPSuccinylornithine transaminase 2.6.1.81 0.668
4dbc 3QPAspartate aminotransferase 2.6.1.1 0.667
1oxo IK2Aspartate aminotransferase, mitochondrial 2.6.1.1 0.665
4jf1 PLPAcetylornithine/succinyldiaminopimelate aminotransferase 2.6.1.11 0.663
4oma LCSMethionine gamma-lyase / 0.662
4yal 2AMNADPH--cytochrome P450 reductase / 0.661
4eb7 PLPCysteine desulfurase IscS 2 / 0.657
4r29 SAMUncharacterized protein / 0.656
4jey PLPAcetylornithine/succinyldiaminopimelate aminotransferase 2.6.1.11 0.655
4eb5 PLPCysteine desulfurase IscS 2 / 0.653
4bqy FNTEgl nine homolog 1 / 0.651
4obu PLPPyridoxal-dependent decarboxylase domain protein / 0.650