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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1byg STU Tyrosine-protein kinase CSK

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1byg STUTyrosine-protein kinase CSK / 0.973
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.801
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.781
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.777
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.766
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.760
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.754
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.754
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.753
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.747
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.746
1xjd STUProtein kinase C theta type 2.7.11.13 0.746
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.740
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.734
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.733
3zew STUEphrin type-B receptor 4 2.7.10.1 0.731
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.727
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.724
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.720
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.720
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.720
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.711
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.709
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.709
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.695
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.690
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.689
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.689
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.689
3d7t STUTyrosine-protein kinase CSK / 0.686
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.673
4e5f 0N7Polymerase acidic protein / 0.660
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.656
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.655
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.652
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.650