sc-PDB

List of CHEMBLId :

This value allows a number of roughly comparable measures of half-maximal response concentration/potency/affinity to be compared on a negative logarithmic scale (e.g., an IC50 measurement of 1nM would have a pChEMBL value of 9).

Uniprot Annotation

Name:	Lysine--tRNA ligase
ID:	SYK_HUMAN
AC:	Q15046
Organism:	Homo sapiens
Reign:	Eukaryota
TaxID:	9606
EC Number:	6.1.1.6

---

Chains:

Chain Name:	Percentage of Residues within binding site
H	100 %

---

Ligand binding site composition:

B-Factor:	33.407
Number of residues:	34
Including
Standard Amino Acids:	33
Non Standard Amino Acids:	1
Water Molecules:	0
Cofactors:
Metals:	MG

---

Cavity properties

Ligandability	Volume (Å3)
0.797	1535.625

% Hydrophobic	% Polar
34.51	65.49
According to VolSite

HET Code:	APC
Formula:	C11H14N5O12P3
Molecular weight:	501.176 g/mol
DrugBank ID:	DB02596
Buried Surface Area:	48.53 %
Polar Surface area:	310.64 Å2

Number of
H-Bond Acceptors:	16
H-Bond Donors:	3
Rings:	3
Aromatic rings:	2
Anionic atoms:	4
Cationic atoms:	0
Rule of Five Violation:	2
Rotatable Bonds:	8

---

Mass center Coordinates

X	Y	Z
52.1686	-10.7191	27.6535

• 2D View
• 3D View