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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
7dfrFOLDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
7dfrFOLDihydrofolate reductase1.5.1.31.000
4nx6FOLDihydrofolate reductase1.5.1.30.673
1dreMTXDihydrofolate reductase1.5.1.30.643
4h9614QDihydrofolate reductase1.5.1.30.616
1rx2FOLDihydrofolate reductase1.5.1.30.610
4nx7FOLDihydrofolate reductase1.5.1.30.608
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.607
1cd2FOLDihydrofolate reductase1.5.1.30.606
2zzaFOLDihydrofolate reductase/0.600
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.598
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.597
4kjjFOLDihydrofolate reductase1.5.1.30.597
3qlrQLRDihydrofolate reductase1.5.1.30.593
3ql3FOLDihydrofolate reductase1.5.1.30.591
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.591
1qzfFOLBifunctional dihydrofolate reductase-thymidylate synthase/0.589
1rh3MTXDihydrofolate reductase1.5.1.30.586
2cd2FOLDihydrofolate reductase1.5.1.30.586
4m7vRARDihydrofolate reductase/0.583
3qly55VUncharacterized protein/0.580
3tq9MTXDihydrofolate reductase/0.580
4ixeIXEDihydrofolate reductase1.5.1.30.579
1ia1TQ3Dihydrofolate reductase1.5.1.30.578
1klkPMDDihydrofolate reductase1.5.1.30.578
3qlxQLRUncharacterized protein/0.578
2fziDH3Dihydrofolate reductase1.5.1.30.577
3fywXCFDihydrofolate reductase1.5.1.30.575
3freTOPDihydrofolate reductase1.5.1.30.574
3srsM23Dihydrofolate reductase1.5.1.30.572
3tqbFOLDihydrofolate reductase/0.569
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.569
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.569
1m79MQ1Dihydrofolate reductase1.5.1.30.568
3cseN22Uncharacterized protein/0.567
4x5gFOLDihydrofolate reductase1.5.1.30.567
4x5fFOLDihydrofolate reductase1.5.1.30.566
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.564
1ra2FOLDihydrofolate reductase1.5.1.30.562
3fy8XCFDihydrofolate reductase1.5.1.30.562
3tq8TOPDihydrofolate reductase/0.562
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.561
1dyrTOPDihydrofolate reductase1.5.1.30.560
4g8zTOPDihydrofolate reductase1.5.1.30.559
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.557
1ia2TQ4Dihydrofolate reductase1.5.1.30.556
3qls55VDihydrofolate reductase1.5.1.30.556
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.554
3dfrMTXDihydrofolate reductase1.5.1.30.553
3sgy06WDihydrofolate reductase1.5.1.30.552
3eek53SUncharacterized protein/0.551
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.550
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.550
4h9506UDihydrofolate reductase1.5.1.30.549
3fyvXCFDihydrofolate reductase1.5.1.30.548
4ixgIXGDihydrofolate reductase1.5.1.30.548
3sh25DRDihydrofolate reductase1.5.1.30.546
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.544
3sqyQ11Dihydrofolate reductase1.5.1.30.544
1ia3TQ5Dihydrofolate reductase1.5.1.30.542
4h9814QUncharacterized protein/0.542
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.541
3eem53VUncharacterized protein/0.541
3sa16DRDihydrofolate reductase/0.541
3sr5Q12Dihydrofolate reductase1.5.1.30.540
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.540
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.539
1kmsLIHDihydrofolate reductase1.5.1.30.537
2cig1DGDihydrofolate reductase1.5.1.30.537
2fzjDH3Dihydrofolate reductase1.5.1.30.537
3sai9DRDihydrofolate reductase/0.537
3oafOAGDihydrofolate reductase1.5.1.30.536
3ddw055Glycogen phosphorylase, liver form2.4.1.10.534
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.533
4kebFOLDihydrofolate reductase1.5.1.30.531
4ixfIXFDihydrofolate reductase1.5.1.30.530
4p66MTXDihydrofolate reductase/0.530
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.529
1ia4TQ6Dihydrofolate reductase1.5.1.30.528
4m2xTMQDihydrofolate reductase1.5.1.30.528
3eel53TUncharacterized protein/0.527
1jomFFODihydrofolate reductase1.5.1.30.526
3qlsNDPDihydrofolate reductase1.5.1.30.526
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.524
3i8aN22Dihydrofolate reductase1.5.1.30.524
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.523
3qlwN22Dihydrofolate reductase1.5.1.30.523
4m6l21VDihydrofolate reductase1.5.1.30.523
4p68MTXDihydrofolate reductase/0.522
1ddrMTXDihydrofolate reductase1.5.1.30.521
3gyf51PDihydrofolate reductase1.5.1.30.520
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.519
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.518
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.518
1e26GPBDihydrofolate reductase1.5.1.30.517
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.516
3rg9WRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.514
3koo24DBifunctional epoxide hydrolase 23.3.2.100.513
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.509
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.509
5cccDDFDihydrofolate reductase1.5.1.30.509
1rc4DDFDihydrofolate reductase1.5.1.30.507
1drbMTXDihydrofolate reductase1.5.1.30.506
3m09RARDihydrofolate reductase1.5.1.30.505
4fhbFOLDihydrofolate reductase1.5.1.30.505
3l3rOAGDihydrofolate reductase1.5.1.30.504
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.504
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.503
3h1vTK1Glucokinase2.7.1.20.503
3jwm5WBDihydrofolate reductase/0.503
4hni16WCasein kinase I isoform epsilon2.7.11.10.503
3k47D09Dihydrofolate reductase1.5.1.30.502
4ele31IDihydrofolate reductase/0.502
2c3oTPPPyruvate synthase/0.501
3eej53RUncharacterized protein/0.501
3zhbNAPPutative dehydrogenase/0.501
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.500
3nr4PYVAbscisic acid receptor PYL2/0.500
1ly4COQDihydrofolate reductase1.5.1.30.499
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.499
2w3wVG9Dihydrofolate reductase/0.499
3d84NDPDihydrofolate reductase1.5.1.30.498
3h3r14HCollagen type IV alpha-3-binding protein/0.498
4kne1CYDihydrofolate reductase1.5.1.30.497
1og5SWFCytochrome P450 2C9/0.496
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.496
3d80Q22Dihydrofolate reductase1.5.1.30.494
3s7a684Dihydrofolate reductase1.5.1.30.494
1db1VDXVitamin D3 receptor/0.492
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.492
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.492
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.492
1re7FOLDihydrofolate reductase1.5.1.30.491
1rx8FOLDihydrofolate reductase1.5.1.30.491
1s3yTQTDihydrofolate reductase1.5.1.30.491
3drcMTXDihydrofolate reductase1.5.1.30.491
3nxyD2HDihydrofolate reductase1.5.1.30.491
1rx1NAPDihydrofolate reductase1.5.1.30.490
3nxxNDPDihydrofolate reductase1.5.1.30.490
4wx2F6FTryptophan synthase alpha chain/0.490
4wx2F6FTryptophan synthase beta chain4.2.1.200.490
4zasTYDCalS13/0.490
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.489
2ayrL4GEstrogen receptor/0.489
3lfcZ86Mitogen-activated protein kinase 14/0.489
4nh82LCHeat shock protein HSP 90-alpha/0.489
4qi9MTXDihydrofolate reductase/0.489
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.488
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.488
3nxvD2FDihydrofolate reductase1.5.1.30.488
3sa27DRDihydrofolate reductase/0.488
4awo99BHeat shock protein HSP 90-alpha/0.488
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.488
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.488
1zdwFLVPrenyltransferase/0.487
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.487
3tkyN7I(Iso)eugenol O-methyltransferase2.1.1.1460.487
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.487
1diuBDMDihydrofolate reductase1.5.1.30.486
1gj5130Prothrombin3.4.21.50.486
3qlrNDPDihydrofolate reductase1.5.1.30.486
4ddrMMVDihydrofolate reductase1.5.1.30.486
4dfrMTXDihydrofolate reductase1.5.1.30.486
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.486
1ie9VDXVitamin D3 receptor/0.485
1td2PXLPyridoxal kinase PdxY/0.485
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.485
2wueKEK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.485
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.485
4jlj1NMDeoxycytidine kinase2.7.1.740.485
1qknRALEstrogen receptor beta/0.484
1rp4FADEndoplasmic oxidoreductin-11.8.40.484
4k9yK9YFocal adhesion kinase 12.7.10.20.484
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.483
2h55DZ8Heat shock protein HSP 90-alpha/0.483
2hcdBIVVitamin D3 receptor A/0.483
2wjoQUDBeta-secretase 13.4.23.460.483
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.483
3a0iAJIGlucokinase2.7.1.20.483
3mnrSD1Heat shock protein HSP 90-alpha/0.483
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.483
3reoEUG(Iso)eugenol O-methyltransferase2.1.1.1460.483
3up3XCAaceDAF-12/0.483
3w0hW12Vitamin D3 receptor/0.483
1s3uTQDDihydrofolate reductase1.5.1.30.482
1s4dSAHUroporphyrinogen-III C-methyltransferase2.1.1.1070.482
2yejXQKHeat shock protein HSP 90-alpha/0.482
3h3sH15Collagen type IV alpha-3-binding protein/0.482
1jolFFODihydrofolate reductase1.5.1.30.481
5d7qAR6NAD-dependent protein deacetylase sirtuin-23.5.10.481
1pd9CO4Dihydrofolate reductase1.5.1.30.480
1rd7FOLDihydrofolate reductase1.5.1.30.480
2po7CHDFerrochelatase, mitochondrial4.99.1.10.480
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.480
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.480
4hy6FJ1Heat shock protein HSP 90-alpha/0.480
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.480
2e0nSAHPrecorrin-2 C20-methyltransferase/0.479
3cth319Hepatocyte growth factor receptor2.7.10.10.479
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.479
4iw8KN3Estrogen receptor/0.479
1dhfFOLDihydrofolate reductase1.5.1.30.478
1dhiMTXDihydrofolate reductase1.5.1.30.478
1mvsDTMDihydrofolate reductase1.5.1.30.478
2hb8MVDVitamin D3 receptor/0.478
3eigMTXDihydrofolate reductase1.5.1.30.478
3m31FADEndoplasmic oxidoreductin-11.8.40.478
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.478
4mlhVO2Glucokinase2.7.1.20.478
4x5jFOLDihydrofolate reductase1.5.1.30.478
1dr3TAPDihydrofolate reductase1.5.1.30.477
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.477
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.477
3gcq1BUMitogen-activated protein kinase 14/0.477
4isg1FYGlucokinase2.7.1.20.477
5eccNAPDehydrofolate reductase type I/0.477
1jtqLY3Thymidylate synthase/0.476
2acwUPGGlycosyltransferase/0.476
2w3bNDPDihydrofolate reductase1.5.1.30.476
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.476
4g20484Vitamin D3 receptor A/0.476
4o95245Cytokinin dehydrogenase 4/0.476
3pwhZMAAdenosine receptor A2a/0.476
1bzfTMQDihydrofolate reductase1.5.1.30.475
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.475
1z6tADPApoptotic protease-activating factor 1/0.475
1zw9H64ATP-dependent molecular chaperone HSP82/0.475
2fszOHTEstrogen receptor beta/0.475
3nj0PYVAbscisic acid receptor PYL2/0.475
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.475
5a28MYAGlycylpeptide N-tetradecanoyltransferase/0.475
5d7pAR6NAD-dependent protein deacetylase sirtuin-23.5.10.475
1ia1NDPDihydrofolate reductase1.5.1.30.474
1kmvLIIDihydrofolate reductase1.5.1.30.474
1rb2FOLDihydrofolate reductase1.5.1.30.474
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
2hasC3OVitamin D3 receptor/0.474
2qk8MTXDihydrofolate reductase/0.474
2wi72KLHeat shock protein HSP 90-alpha/0.474
2yejZZ3Heat shock protein HSP 90-alpha/0.474
3h4vNAPPteridine reductase 11.5.1.330.474
3nxrD2DDihydrofolate reductase1.5.1.30.474
3tdaPN0Cytochrome P450 2D6/0.474
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.474
4elb34SDihydrofolate reductase/0.474
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.474
4kbn25UDihydrofolate reductase1.5.1.30.474
1drhNAPDihydrofolate reductase1.5.1.30.473
1m78NDPDihydrofolate reductase1.5.1.30.473
1r2jFADFkbI/0.473
1s3wTQTDihydrofolate reductase1.5.1.30.473
1uy9PU6Heat shock protein HSP 90-alpha/0.473
1uydPU8Heat shock protein HSP 90-alpha/0.473
2w6qOA5Biotin carboxylase6.3.4.140.473
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.473
4x5iFOLDihydrofolate reductase1.5.1.30.473
1bozPRDDihydrofolate reductase1.5.1.30.472
1bwlFMNNADPH dehydrogenase 11.6.99.10.472
1ludTRRDihydrofolate reductase1.5.1.30.472
1uy8PU5Heat shock protein HSP 90-alpha/0.472
2drcMTXDihydrofolate reductase1.5.1.30.472
3fl8RARDihydrofolate reductase/0.472
3nxoD2BDihydrofolate reductase1.5.1.30.472
4g95OAGDihydrofolate reductase1.5.1.30.472
1hfqMOTDihydrofolate reductase1.5.1.30.471
1xp9AIJEstrogen receptor/0.471
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.471
3nglNAPBifunctional protein FolD/0.471
3tqxPLP2-amino-3-ketobutyrate coenzyme A ligase/0.471
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.471
5jtbZMAAdenosine receptor A2a/0.471
1x8b824Wee1-like protein kinase2.7.10.20.470
2oaxSNLMineralocorticoid receptor/0.470
2pdaTPPPyruvate synthase/0.470
2ywvADPPhosphoribosylaminoimidazole-succinocarboxamide synthase/0.470
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.470
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.470
3n0hTOPDihydrofolate reductase1.5.1.30.470
4kl9NDPDihydrofolate reductase1.5.1.30.470
4l8u9AZSerum albumin/0.470
1dr2TAPDihydrofolate reductase1.5.1.30.469
1rx4DDFDihydrofolate reductase1.5.1.30.469
1u3r338Estrogen receptor beta/0.469
2hb7O1CVitamin D3 receptor/0.469
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
2pl0STITyrosine-protein kinase Lck2.7.10.20.469
2w9hTOPDihydrofolate reductase1.5.1.30.469
4g1z0VPVitamin D3 receptor A/0.469
4ia1BIVVitamin D3 receptor A/0.469
4zqcF6FTryptophan synthase alpha chain/0.469
5il2SAHN6-adenosine-methyltransferase 70 kDa subunit/0.469
1s19MC9Vitamin D3 receptor/0.468
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.468
2ociTYCValacyclovir hydrolase3.10.468
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
3hv3R49Mitogen-activated protein kinase 14/0.468
3hz5Z64Heat shock protein HSP 90-alpha/0.468
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.468
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
3vrvYSDVitamin D3 receptor/0.468
4dhyS41Glucokinase2.7.1.20.468
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.468
4m6kFOLDihydrofolate reductase1.5.1.30.468
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.467
1yqj6NPMitogen-activated protein kinase 14/0.467
2fwyH64Heat shock protein HSP 90-alpha/0.467
2o4jVD4Vitamin D3 receptor/0.467
2puiADPMethylthioribose kinase2.7.1.1000.467
2q7gCCLPyrrolysine--tRNA ligase/0.467
2vssACOHydroxycinnamoyl-CoA hydratase-lyase4.1.2.410.467
2wotZZGTGF-beta receptor type-12.7.11.300.467
3vrwYS5Vitamin D3 receptor/0.467
1g28FMNPHY3/0.466
1upw444Oxysterols receptor LXR-beta/0.466
2w3aTOPDihydrofolate reductase1.5.1.30.466
2ykbYKBHeat shock protein HSP 90-alpha/0.466
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.466
3drrR8EGag-Pol polyprotein2.7.7.490.466
3kpzZNEVitamin D3 receptor/0.466
3m7rVDXVitamin D3 receptor/0.466
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
1ai9NDPDihydrofolate reductase1.5.1.30.465
1bq1CB3Thymidylate synthase/0.465
1rx5DDFDihydrofolate reductase1.5.1.30.465
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.465
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.465
3zze6XPHepatocyte growth factor receptor2.7.10.10.465
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4iah1DXAlr2278 protein/0.465
4iui1GQEstrogen receptor/0.465
4iv21GREstrogen receptor/0.465
4knnE1FCarbonic anhydrase 134.2.1.10.465
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.465
5ai5BSUBifunctional epoxide hydrolase 23.1.3.760.465
1ay0TPPTransketolase 12.2.1.10.464
1oc1ASVIsopenicillin N synthase1.21.3.10.464
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.464
2egsSAHDiphthine synthase/0.464
2p2xSAHDiphthine synthase/0.464
2vcmM11Isopenicillin N synthase1.21.3.10.464
2wpxACOOrf14/0.464
3ld6BCDLanosterol 14-alpha demethylase1.14.13.700.464
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
3pi0F91Endothiapepsin3.4.23.220.464
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
4nmbFADBifunctional protein PutA/0.464
5dp2NAPCurF/0.464
1ml6GBXGlutathione S-transferase A22.5.1.180.463
3imxB84Glucokinase2.7.1.20.463
3up0D7SaceDAF-12/0.463
3w0yDS4Vitamin D3 receptor/0.463
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
1fkwPURAdenosine deaminase3.5.4.40.462
1hfrMOTDihydrofolate reductase1.5.1.30.462
1kekHTLPyruvate synthase/0.462
1uyePU9Heat shock protein HSP 90-alpha/0.462
2bakAQZMitogen-activated protein kinase 14/0.462
2hamC33Vitamin D3 receptor/0.462
2jfaRALEstrogen receptor/0.462
2yee2ECHeat shock protein HSP 90-alpha/0.462
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.462
3nrcTCLEnoyl-[acyl-carrier-protein] reductase [NADH]/0.462
4a9yAQZMitogen-activated protein kinase 14/0.462
4ce3L4VATP-dependent molecular chaperone HSP82/0.462
4esoNAPPutative oxidoreductase/0.462
4jq8KJ8Epidermal growth factor receptor2.7.10.10.462
4ocvANPAminoglycoside phosphotransferase/0.462
4rupH97Vitamin D3 receptor A/0.462
5d7pOCZNAD-dependent protein deacetylase sirtuin-23.5.10.462
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.461
1olmVTQSEC14-like protein 2/0.461
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.461
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.461
1uxjNADMalate dehydrogenase/0.461
2ykcYKCHeat shock protein HSP 90-alpha/0.461
3c3dFO12-phospho-L-lactate transferase/0.461
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.461
3vt65YIVitamin D3 receptor/0.461
4bqrIBHEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
4dphP65Bifunctional dihydrofolate reductase-thymidylate synthase/0.461
4elg52JDihydrofolate reductase/0.461
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.461
4ruoBIVVitamin D3 receptor A/0.461
1bsvNDPGDP-L-fucose synthase/0.460
1dr3HBIDihydrofolate reductase1.5.1.30.460
1f4fTP3Thymidylate synthase/0.460
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.460
2cjpVPREpoxide hydrolase/0.460
2y60M8FIsopenicillin N synthase1.21.3.10.460
3dolGWIPol protein/0.460
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.460
3o0iP54Heat shock protein HSP 90-alpha/0.460
3o9lLPNRenin3.4.23.150.460
4ap7F47Hepatocyte growth factor receptor2.7.10.10.460
4j6dTESCytochrome P450 monooxygenase/0.460
4j7xSASSepiapterin reductase1.1.1.1530.460
4wqmFADToluene-4-monooxygenase electron transfer component1.18.1.30.460
4y6gF6FTryptophan synthase alpha chain/0.460
5k2bZMAAdenosine receptor A2a/0.460
1hfpMOTDihydrofolate reductase1.5.1.30.459
1nq7ARLNuclear receptor ROR-beta/0.459
1wxyFRKAdenosine deaminase3.5.4.40.459
2bxqIMNSerum albumin/0.459
2i1vADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.459
2wo7ASVIsopenicillin N synthase1.21.3.10.459
2wuuNHWGlycylpeptide N-tetradecanoyltransferase/0.459
2yncYNCGlycylpeptide N-tetradecanoyltransferase/0.459
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.459
3l6jZ90Alr2278 protein/0.459
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.459
3qdd94MHeat shock protein HSP 90-alpha/0.459
3s79ASDAromatase1.14.14.140.459
4i8vBHFCytochrome P450 1A11.14.14.10.459
4itfTFYVitamin D3 receptor/0.459
4jlm1NNDeoxycytidine kinase2.7.1.740.459
4jqh1MFAlr2278 protein/0.459
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
4orkGDPBifunctional AAC/APH2.3.10.459
5k2aZMAAdenosine receptor A2a/0.459
1dr4HBIDihydrofolate reductase1.5.1.30.458
1ikgREXD-alanyl-D-alanine carboxypeptidase3.4.16.40.458
1wpgADPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.458
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.458
2ewaSB2Mitogen-activated protein kinase 14/0.458
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
2qw8NAPEugenol synthase 11.1.1.3180.458
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.458
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.458
3i53SAH2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.458
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
3nxtD2EDihydrofolate reductase1.5.1.30.458
4ax8ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.458
4elf35IDihydrofolate reductase/0.458
4fnyI3KALK tyrosine kinase receptor2.7.10.10.458
4g1y0VOVitamin D3 receptor A/0.458
4qa0SHHHistone deacetylase 83.5.1.980.458
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.457
1kzjCB3Thymidylate synthase/0.457
1rf7DHFDihydrofolate reductase1.5.1.30.457
1rg7MTXDihydrofolate reductase1.5.1.30.457
1rkgVD1Vitamin D3 receptor/0.457
1tl7FOKAdenylate cyclase type 2/0.457
1tl7FOKAdenylate cyclase type 5/0.457
2bj4OHTEstrogen receptor/0.457
2c42TPPPyruvate synthase/0.457
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
2uzaHTLPyruvate synthase/0.457
2wpwACOOrf14/0.457
3gl2D3MDdmC/0.457
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.457
3v3m0ENReplicase polyprotein 1a3.4.19.120.457
3vjcZGASqualene synthase2.5.1.210.457
4ap1NAPSteroid monooxygenase/0.457
4bfxZVXPantothenate kinase2.7.1.330.457
4c72TLG3-oxoacyl-ACP synthase/0.457
4dliIRGMitogen-activated protein kinase 14/0.457
4g8bHL6Alpha/beta hydrolase fold protein/0.457
4g8cC6LAlpha/beta hydrolase fold protein/0.457
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.457
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
4lvb20NNicotinamide phosphoribosyltransferase2.4.2.120.457
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.457
1blzACVIsopenicillin N synthase1.21.3.10.456
1mabADPATP synthase subunit beta, mitochondrial3.6.3.140.456
1pkfEPDEpothilone C/D epoxidase1.140.456
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.456
1uykPUXHeat shock protein HSP 90-alpha/0.456
2dhfDZFDihydrofolate reductase1.5.1.30.456
2jedLG8Protein kinase C theta type2.7.11.130.456
2vbpVB1Isopenicillin N synthase1.21.3.10.456
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.456
2zjmF1MBeta-secretase 13.4.23.460.456
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.456
3b6zCO7Enoyl reductase LovC10.456
3f8kCOAUncharacterized protein/0.456
3hz142CHeat shock protein HSP 90-alpha/0.456
3itzP66Mitogen-activated protein kinase 14/0.456
3lakKR1Gag-Pol polyprotein2.7.7.490.456
3p9tTCLRepressor/0.456
3t37FADPyridoxine 4-oxidase/0.456
3vi7CBDHematopoietic prostaglandin D synthase/0.456
3zcnATPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.456
3zxzKRWHepatocyte growth factor receptor2.7.10.10.456
4eftEFTHeat shock protein HSP 90-alpha/0.456
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.456
4l17DNQGlutamate receptor 2/0.456
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.456
4rrjA3SProbable threonine--tRNA ligase 26.1.1.30.456
1drfFOLDihydrofolate reductase1.5.1.30.455
1lkdBP6Biphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.455
1pqc444Oxysterols receptor LXR-beta/0.455
1rx6DDFDihydrofolate reductase1.5.1.30.455
1zgaHMKIsoflavone 4'-O-methyltransferase/0.455
2x20PIDPeridinin-chlorophyll a-binding protein 1, chloroplastic/0.455
3eluSAMMethyltransferase/0.455
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
3lm4HPXCatechol 2,3-dioxygenase/0.455
3p6pA6BCamphor 5-monooxygenase1.14.15.10.455
3pd2A3SThreonine--tRNA ligase6.1.1.30.455
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.455
4k9oTPPBenzoylformate decarboxylase4.1.1.70.455
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.455
5uviZMAAdenosine receptor A2a/0.455
3emlZMAAdenosine receptor A2a/0.455
1cjkFOKAdenylate cyclase type 2/0.454
1cjkFOKAdenylate cyclase type 5/0.454
1dr5NAPDihydrofolate reductase1.5.1.30.454
1dtnAPGMandelate racemase/0.454
1kceCB3Thymidylate synthase/0.454
2gjlFMNNitronate monooxygenase1.13.12.160.454
2hl2SSAThreonine--tRNA ligase6.1.1.30.454
2hm9TRRDihydrofolate reductase1.5.1.30.454
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.454
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
2vb8TLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.454
3b05IPEIsopentenyl-diphosphate delta-isomerase/0.454
3br3ETHTH-type transcriptional regulator QacR/0.454
3cluFADElectron transfer flavoprotein subunit alpha/0.454
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
3p6oETGCamphor 5-monooxygenase1.14.15.10.454
3pd4A3GThreonine--tRNA ligase6.1.1.30.454
3ssoSAHMycinamicin VI 2''-O-methyltransferase/0.454
3wnzADPAlanine--anticapsin ligase/0.454
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.454
4c68NHWGlycylpeptide N-tetradecanoyltransferase/0.454
4hu1V13Carbonic anhydrase 134.2.1.10.454
4i1nFOLDihydrofolate reductase1.5.1.30.454
4ie0PD2Alpha-ketoglutarate-dependent dioxygenase FTO/0.454
4j6cSTRCytochrome P450 monooxygenase/0.454
4o71CPBBromodomain-containing protein 4/0.454
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.454
1dhjMTXDihydrofolate reductase1.5.1.30.453
1fmjRTLRetinol dehydratase/0.453
1k6mAGS6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 12.7.1.1050.453
1mlzPLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.453
1rx8NAPDihydrofolate reductase1.5.1.30.453
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.453
1zky689Estrogen receptor/0.453
2cchATPCyclin-dependent kinase 22.7.11.220.453
2oalFADFlavin-dependent tryptophan halogenase RebH1.14.19.90.453
2rhrEMOPutative ketoacyl reductase1.3.10.453
2v2zADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.453
2vttLZDCyclin-dependent kinase 22.7.11.220.453
2ykjYKJHeat shock protein HSP 90-alpha/0.453
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.453
2z6iFMN2-nitropropane dioxygenase/0.453
3akzGSUGlutamate--tRNA ligase 2/0.453
3new3NEMitogen-activated protein kinase 14/0.453
4bmpFMNProtein NrdI/0.453
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
4ia2BIVVitamin D3 receptor A/0.453
4nb6444Nuclear receptor ROR-gamma/0.453
4qjcIXEDihydrofolate reductase1.5.1.30.453
5fkmTDCTetracycline repressor protein class D/0.453
3uzaT4GAdenosine receptor A2a/0.453
1s0zEB1Vitamin D3 receptor/0.452
1xddAAYIntegrin alpha-L/0.452
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.452
2bf7HBIPteridine reductase 11.5.1.330.452
2bjsACVIsopenicillin N synthase1.21.3.10.452
2hxzH7JCathepsin S3.4.22.270.452
3anlSYC1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.452
3inwJZBHeat shock protein HSP 90-alpha/0.452
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
3vt9YI4Vitamin D3 receptor/0.452
3zv5BPYCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.452
4eevL1XHepatocyte growth factor receptor2.7.10.10.452
4ivw1GJEstrogen receptor/0.452
4l0qNADAlcohol dehydrogenase class-3/0.452
4lsl1YQGag-Pol polyprotein2.7.7.490.452
4mfb29TGag-Pol polyprotein2.7.7.490.452
4qysPLRTryptophan synthase beta chain 24.2.1.200.452
1c4vIH2Prothrombin3.4.21.50.451
1qltFADVanillyl-alcohol oxidase1.1.3.380.451
1rkhVD2Vitamin D3 receptor/0.451
1s3vTQDDihydrofolate reductase1.5.1.30.451
1tw2ERTCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.451
1xpcAITEstrogen receptor/0.451
2gj3FADNitrogen fixation regulatory protein2.7.13.30.451
2izkGLLStreptavidin/0.451
2pulACPMethylthioribose kinase2.7.1.1000.451
2r2gEMFEugenol synthase 11.1.1.3180.451
3bgrT27Gag-Pol polyprotein2.7.7.490.451
3nefPYVAbscisic acid receptor PYL1/0.451
3njoPYVAbscisic acid receptor PYR1/0.451
3pahXDEPhenylalanine-4-hydroxylase1.14.16.10.451
3rl35GPMetallophosphoesterase MPPED23.10.451
3t2wBTNAvidin/streptavidin/0.451
3uf6CODLmo1369 protein/0.451
3vtcTK3Vitamin D3 receptor/0.451
3wtkTH4Acetylcholine-binding protein/0.451
4a99MIYTetX family tetracycline inactivation enzyme/0.451
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.451
4fhi0S4Vitamin D3 receptor A/0.451
4gm4TZDBenzoylformate decarboxylase4.1.1.70.451
4k5o1OTM1 family aminopeptidase3.4.110.451
4kak06UDihydrofolate reductase1.5.1.30.451
4n3l2FNProthrombin3.4.21.50.451
4rw4494Gag-Pol polyprotein2.7.7.490.451
4tjy3GNTankyrase-22.4.2.300.451
4tyj0LIFibroblast growth factor receptor 42.7.10.10.451
6coxS58Prostaglandin G/H synthase 21.14.99.10.451
1h35R01Squalene--hopene cyclase4.2.1.1290.450
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.450
1qiqACCIsopenicillin N synthase1.21.3.10.450
1zaf789Estrogen receptor beta/0.450
2apgFADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.450
2yg3FADPutrescine oxidase/0.450
2ykeYKEHeat shock protein HSP 90-alpha/0.450
2z3uCRRCytochrome P450/0.450
2zlcVDXVitamin D3 receptor/0.450
3dleGFAGag-Pol polyprotein2.7.7.490.450
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.450
3k2hLYABifunctional dihydrofolate reductase-thymidylate synthase/0.450
3otqMZLBifunctional epoxide hydrolase 23.3.2.100.450
3qm4PN0Cytochrome P450 2D6/0.450
3w0aDS5Vitamin D3 receptor/0.450
3w5tLHPVitamin D3 receptor/0.450
3x065GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.450
3x0a5GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.450
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.450
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.450
4fj0HHF17beta-hydroxysteroid dehydrogenase/0.450
4fqsLYAThymidylate synthase ThyA/0.450
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4gncASORegucalcin3.1.1.170.450
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.450
4ia3BIVVitamin D3 receptor A/0.450
4jq7KJQEpidermal growth factor receptor2.7.10.10.450
4kfj1R0Dihydrofolate reductase1.5.1.30.450
4mprTPPBenzoylformate decarboxylase4.1.1.70.450
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4z1fH71Heat shock protein 75 kDa, mitochondrial/0.450
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
5k2cZMAAdenosine receptor A2a/0.450
1ie8KH1Vitamin D3 receptor/0.449
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.449
1s7gNADNAD-dependent protein deacylase 2/0.449
1svlADPLarge T antigen3.6.40.449
1txiTX5Vitamin D3 receptor/0.449
1uyhPU0Heat shock protein HSP 90-alpha/0.449
1ykdCMPAdenylate cyclase/0.449
2ban357Gag-Pol polyprotein2.7.7.490.449
2hc4VDXVitamin D3 receptor A/0.449
2x7jTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.449
2zhf49UProthrombin3.4.21.50.449
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.449
3gluLYS_VAL_METNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.449
3hz137DHeat shock protein HSP 90-alpha/0.449
3kk6CELProstaglandin G/H synthase 11.14.99.10.449
3ry2BTNStreptavidin/0.449
3tubFPUTyrosine-protein kinase SYK2.7.10.20.449
3uvvREARetinoic acid receptor RXR-alpha/0.449
3w0c6DSVitamin D3 receptor/0.449
3w0iO11Vitamin D3 receptor/0.449
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4c73TLH3-oxoacyl-ACP synthase/0.449
4cukNAID-lactate dehydrogenase/0.449
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4gg70J8Hepatocyte growth factor receptor2.7.10.10.449
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.449
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4rquNADAlcohol dehydrogenase class-P/0.449
4rrmA3TProbable threonine--tRNA ligase 26.1.1.30.449
3reyXACAdenosine receptor A2a/0.449
1dyhDZFDihydrofolate reductase1.5.1.30.448
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1ove358Mitogen-activated protein kinase 14/0.448
1q5dEPBEpothilone C/D epoxidase1.140.448
1rx7FOLDihydrofolate reductase1.5.1.30.448
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2ewnBTXBifunctional ligase/repressor BirA/0.448
2h94FADLysine-specific histone demethylase 1A10.448
2hl1A3SThreonine--tRNA ligase6.1.1.30.448
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.448
2p1v5TNRetinoic acid receptor RXR-alpha/0.448
2pcaSAHDiphthine synthase/0.448
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.448
2x9dITCTetracycline repressor protein class D/0.448
2zynBCDPeriplasmic binding protein/0.448
3adaNADSubunit alpha of sarocosine oxidase/0.448
3b05FNRIsopentenyl-diphosphate delta-isomerase/0.448
3c1oNAPEugenol synthase/0.448
3c3xNAPEugenol synthase 11.1.1.3180.448
3cgbCOACoenzyme A disulfide reductase/0.448
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.448
3pm1ETHTH-type transcriptional regulator QacR/0.448
3saz043Malate synthase G/0.448
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.448
4bb3KKAIsopenicillin N synthase1.21.3.10.448
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4briUNPEctonucleoside triphosphate diphosphohydrolase I/0.448
4cdmFO1Deoxyribodipyrimidine photolyase/0.448
4dch4DCGlucokinase2.7.1.20.448
4eiyZMAAdenosine receptor A2a/0.448
4kttSAMS-adenosylmethionine synthase isoform type-22.5.1.60.448
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.448
1aj22PHDihydropteroate synthase/0.447
1d4pBPPProthrombin3.4.21.50.447
1disBDMDihydrofolate reductase1.5.1.30.447
1dljUGAUDP-glucose 6-dehydrogenase/0.447
1dnaCB3Thymidylate synthase/0.447
1srhMOBStreptavidin/0.447
1synF89Thymidylate synthase/0.447
1uyfPU1Heat shock protein HSP 90-alpha/0.447
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.447
2bfpH4BPteridine reductase 11.5.1.330.447
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.447
2nniMTKCytochrome P450 2C8/0.447
2punACPMethylthioribose kinase2.7.1.1000.447
3a8wATPProtein kinase C iota type2.7.11.130.447
3antS82Bifunctional epoxide hydrolase 23.3.2.100.447
3b03VNRIsopentenyl-diphosphate delta-isomerase/0.447
3gwfNAPCyclohexanone monooxygenase/0.447
3nmpPYVAbscisic acid receptor PYL2/0.447
3pllF06Endothiapepsin3.4.23.220.447
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.447
3qtsX46Cyclin-dependent kinase 22.7.11.220.447
3vt45YIVitamin D3 receptor/0.447
3w5q3KLVitamin D3 receptor/0.447
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.447
4a83DXCMajor pollen allergen Bet v 1-A/0.447
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.447
4kfbT27Gag-Pol polyprotein2.7.7.490.447
4rrlA3SProbable threonine--tRNA ligase 26.1.1.30.447
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
4uyg73BBromodomain-containing protein 2/0.447
4xx0COASuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial6.2.1.40.447
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.447
5iubCLRAdenosine receptor A2a/0.447
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
1jtuLYBThymidylate synthase/0.446
1m2pHNACasein kinase II subunit alpha2.7.11.10.446
1rk3VDXVitamin D3 receptor/0.446
1tduDURThymidylate synthase/0.446
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
1upcTPPN(2)-(2-carboxyethyl)arginine synthase/0.446
2e07SAHDiphthine synthase/0.446
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2pupADPMethylthioribose kinase2.7.1.1000.446
2q9fC3SCholesterol 24-hydroxylase/0.446
2r0pK2CPutative FAD-monooxygenase/0.446
2rqfJH3Hemolymph juvenile hormone binding protein/0.446
2wsaMYAGlycylpeptide N-tetradecanoyltransferase/0.446
2y5s78HDihydropteroate synthase/0.446
2yx6ADPUncharacterized protein/0.446
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.446
3gep24HHypoxanthine-guanine phosphoribosyltransferase2.4.2.80.446
3is9AC7Gag-Pol polyprotein2.7.7.490.446
3wsbRWZFarnesyltransferase, putative/0.446
4bbhNHWGlycylpeptide N-tetradecanoyltransferase/0.446
4c3yANB3-ketosteroid dehydrogenase/0.446
4e0u0MVCyclic dipeptide N-prenyltransferase/0.446
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4g2fC07Ephrin type-A receptor 32.7.10.10.446
4gkm683Anthranilate phosphoribosyltransferase/0.446
4kb81QOCasein kinase I isoform delta2.7.11.10.446
4kwi1TJReductase homolog/0.446
4rrhA3SProbable threonine--tRNA ligase 26.1.1.30.446
5ifyTRHGlucose-1-phosphate thymidylyltransferase/0.446
5k2dZMAAdenosine receptor A2a/0.446
1c1bGCAGag-Pol polyprotein2.7.7.490.445
1di8DTQCyclin-dependent kinase 22.7.11.220.445
1dubCAAEnoyl-CoA hydratase, mitochondrial4.2.1.170.445
1gj4132Prothrombin3.4.21.50.445
1mk5BTNStreptavidin/0.445
1ny2ARG_PRO_PRO_GLYProthrombin3.4.21.50.445
1qjfACSIsopenicillin N synthase1.21.3.10.445
1rszDIHPurine nucleoside phosphorylase2.4.2.10.445
1sbrVIBPutative HMP/thiamine-binding protein YkoF/0.445
1tkaN3TTransketolase 12.2.1.10.445
1u0hONMAdenylate cyclase type 2/0.445
1u0hONMAdenylate cyclase type 5/0.445
2eglSAHDiphthine synthase/0.445
2gqfFADUncharacterized protein HI_0933/0.445
2j9lATPH(+)/Cl(-) exchange transporter 5/0.445
2lfoGCHFatty acid-binding protein, liver/0.445
2rl2UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
2xrlDXTTetracycline repressor protein class D/0.445
2yw9NAPEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
3dmjGWEPol protein/0.445
3fklFKLMitogen-activated protein kinase 14/0.445
3kt8LTNTryptophan--tRNA ligase, cytoplasmic6.1.1.20.445
3lu8IQXSerum albumin/0.445
3tfn2CJDehydrosqualene synthase/0.445
3vt5YI2Vitamin D3 receptor/0.445
3w0gW07Vitamin D3 receptor/0.445
3zvuA8SAbscisic acid receptor PYR1/0.445
4at5MUJBDNF/NT-3 growth factors receptor2.7.10.10.445
4awq592Heat shock protein HSP 90-alpha/0.445
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4i2q1BTGag-Pol polyprotein2.7.7.490.445
4ixc1JDGlucokinase2.7.1.20.445
4jbtASDCytochrome P450 monooxygenase/0.445
4rrkA3TProbable threonine--tRNA ligase 26.1.1.30.445
5gcnCOAHAT A1/0.445
1fbyREARetinoic acid receptor RXR-alpha/0.444
1fw0KAIGlutamate receptor 2/0.444
1lbbKAIGlutamate receptor 2/0.444
1rftPXMPyridoxal kinase2.7.1.350.444
1s6qTPBGag-Pol polyprotein2.7.7.490.444
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.444
2bdyUNBProthrombin3.4.21.50.444
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
2jf9OHTEstrogen receptor/0.444
2wdqCBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.444
2wdqCBESuccinate dehydrogenase cytochrome b556 subunit/0.444
2wgjVGHHepatocyte growth factor receptor2.7.10.10.444
2wqpWQPPolysialic acid capsule biosynthesis protein SiaC/0.444
3c6uM22Gag-Pol polyprotein2.7.7.490.444
3fu83DMLaccase-11.10.3.20.444
3fwfCAMCamphor 5-monooxygenase1.14.15.10.444
3kb0A8SAbscisic acid receptor PYL2/0.444
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.444
3pre3REPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3zkuHCVIsopenicillin N synthase1.21.3.10.444
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.444
4h380YXDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.444
4j26ESTEstrogen receptor beta/0.444
4lgaA2OAbscisic acid receptor PYL2/0.444
4rgsV55Repressor protein/0.444
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.444
1bk0ACVIsopenicillin N synthase1.21.3.10.443
1cjtFOKAdenylate cyclase type 2/0.443
1cjtFOKAdenylate cyclase type 5/0.443
1culFOKAdenylate cyclase type 2/0.443
1culFOKAdenylate cyclase type 5/0.443
1jg0DDTThymidylate synthase/0.443
1kuvCA5Serotonin N-acetyltransferase/0.443
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
1s4eADPGalactokinase/0.443
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.443
1t4v14AProthrombin3.4.21.50.443
1uy6PU3Heat shock protein HSP 90-alpha/0.443
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.443
2ftoTMPThymidylate synthase/0.443
2fwzH71Heat shock protein HSP 90-alpha/0.443
2fzwNADAlcohol dehydrogenase class-31.1.1.10.443
2h00SAHU6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase/0.443
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.443
2ihuTP9N(2)-(2-carboxyethyl)arginine synthase/0.443
2o4rVD5Vitamin D3 receptor/0.443
2pnuENMAndrogen receptor/0.443
2v3wTPPBenzoylformate decarboxylase4.1.1.70.443
2zb45OPProstaglandin reductase 21.3.1.480.443
3a783EVVitamin D3 receptor/0.443
3d5fL41Peroxisome proliferator-activated receptor delta/0.443
3dds26BGlycogen phosphorylase, liver form2.4.1.10.443
3ft8MOJHeat shock protein HSP 90-alpha/0.443
3gieACPSensor histidine kinase DesK2.7.13.30.443
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.443
3lqfNADGalactitol dehydrogenase/0.443
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.443
3pgiF41Endothiapepsin3.4.23.220.443
3tx1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.443
3wo0ADPAlanine--anticapsin ligase/0.443
3zsgT75Mitogen-activated protein kinase 14/0.443
4ead0NPThymidine phosphorylase2.4.2.40.443
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.443
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.443
4imoPWZProstaglandin-H2 D-isomerase5.3.99.20.443
4ixd1HVIntegrin alpha-L/0.443
4qa2SHHHistone deacetylase 83.5.1.980.443
4rujVDXVitamin D3 receptor A/0.443
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/0.443
5a3cNADSIR2 family protein/0.443
5cwa0GAAnthranilate synthase component 14.1.3.270.443
3uzcT4EAdenosine receptor A2a/0.443
1d3dBZTProthrombin3.4.21.50.442
1f5fDHTSex hormone-binding globulin/0.442
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1jx0DFVChalcone--flavonone isomerase 15.5.1.60.442
1rjkVDZVitamin D3 receptor/0.442
1x8lOXRRetinol dehydratase/0.442
2cleF6FTryptophan synthase alpha chain/0.442
2e95B75Geranylgeranyl pyrophosphate synthase/0.442
2ekaSAHDiphthine synthase/0.442
2giuFBREstrogen receptor beta/0.442
2hg1N5OEndoplasmin/0.442
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.442
2j9gANPBiotin carboxylase6.3.4.140.442
2p1t3TNRetinoic acid receptor RXR-alpha/0.442
2wbaFADTrypanothione reductase1.8.1.120.442
2xvv9DNSerum albumin/0.442
3h3t16HCollagen type IV alpha-3-binding protein/0.442
3h4vDVPPteridine reductase 11.5.1.330.442
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3l63CAMCamphor 5-monooxygenase1.14.15.10.442
3ns2PYVAbscisic acid receptor PYL2/0.442
3q0gBCOProbable enoyl-CoA hydratase echA84.2.1.170.442
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3w0pADPHygromycin-B 4-O-kinase2.7.1.1630.442
4c02TAKActivin receptor type-12.7.11.300.442
4dbzNDPPutative ketoacyl reductase1.3.10.442
4egnTWOCytochrome P450/0.442
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.442
4ia7BIVVitamin D3 receptor A/0.442
4iaq2GM5-hydroxytryptamine receptor 1B/0.442
4lsjLSJGlucocorticoid receptor/0.442
4mv3ACPBiotin carboxylase6.3.4.140.442
4uyf73BBromodomain-containing protein 2/0.442
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.442
5iu4ZMAAdenosine receptor A2a/0.442
1ao8MTXDihydrofolate reductase1.5.1.30.441
1flmFMNFMN-binding protein/0.441
1h51FMNPentaerythritol tetranitrate reductase/0.441
1kqwRTLCellular retinol-binding protein type II/0.441
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
1rq1FADEndoplasmic oxidoreductin-11.8.40.441
1uhlMEIRetinoic acid receptor RXR-beta/0.441
1zq5E04Aldo-keto reductase family 1 member C3/0.441
2aclREARetinoic acid receptor RXR-alpha/0.441
2d0kFOLDihydrofolate reductase1.5.1.30.441
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.441
2vnkFADNADPH:ferredoxin reductase/0.441
2zl9VDAVitamin D3 receptor/0.441
3ezrEZRCyclin-dependent kinase 22.7.11.220.441
3fhxPXLPyridoxal kinase2.7.1.350.441
3fsuC2F5,10-methylenetetrahydrofolate reductase1.5.1.200.441
3gb4D3MDdmC/0.441
3havATPAminoglycoside phosphotransferase/0.441
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.441
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.441
3zuxTCHTransporter/0.441
4fevPP1Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.441
4ffrATPUncharacterized protein/0.441
4ie6UN9Alpha-ketoglutarate-dependent dioxygenase FTO/0.441
4m8hR4MRetinoic acid receptor RXR-alpha/0.441
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4rraA3TProbable threonine--tRNA ligase 26.1.1.30.441
4y1bNAPAntE/0.441
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.441
3sn6P0GBeta-2 adrenergic receptor/0.441
1f20FADNitric oxide synthase, brain1.14.13.390.440
1jr4CL4Catechol O-methyltransferase2.1.1.60.440
1o2g696Prothrombin3.4.21.50.440
1pq944BOxysterols receptor LXR-beta/0.440
1qoqIGPTryptophan synthase alpha chain/0.440
1rt7UC4Gag-Pol polyprotein2.7.7.490.440
1swtBTNStreptavidin/0.440
1thnADPAnti-sigma F factor/0.440
1yqxNAPSinapyl alcohol dehydrogenase/0.440
2bxmIMNSerum albumin/0.440
2dv3SAHDiphthine synthase/0.440
2harOCCVitamin D3 receptor/0.440
2qe4JJ3Estrogen receptor/0.440
2rkiTT1Gag-Pol polyprotein2.7.7.490.440
2rtoIMIStreptavidin/0.440
2v58LZJBiotin carboxylase6.3.4.140.440
2zfq45UProthrombin3.4.21.50.440
2zreAGSProtein RecA/0.440
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.440
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3iisPIDPeridinin-chlorophyll a-binding protein 1, chloroplastic/0.440
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
3t7x4SHEndothiapepsin3.4.23.220.440
4ckcSAHmRNA-capping enzyme catalytic subunit2.1.1.560.440
4enhFVXCholesterol 24-hydroxylase/0.440
4i7fNVEGag-Pol polyprotein2.7.7.490.440
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.440
4py6R78Bromodomain protein, putative/0.440
5cb5APRO-acetyl-ADP-ribose deacetylase/0.440