sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5kp2 | COA | 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 5kp2 | COA | 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2 | / | 1.000 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.468 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.468 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.466 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.466 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.454 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.453 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.452 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.451 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.450 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.450 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.449 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.448 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.448 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.447 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.445 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.443 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.443 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.443 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.441 | |
| 3up0 | D7S | aceDAF-12 | / | 0.441 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.440 |