sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5it1 | 2OH | Putative cytochrome P450 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 5it1 | 2OH | Putative cytochrome P450 | / | 1.000 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.519 | |
| 3eql | MXP | DNA-directed RNA polymerase subunit beta | / | 0.482 | |
| 3eql | MXP | DNA-directed RNA polymerase subunit beta' | / | 0.482 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.481 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.481 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.480 | |
| 1cbs | REA | Cellular retinoic acid-binding protein 2 | / | 0.479 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.479 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.478 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.477 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.476 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.475 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.473 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.472 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.471 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.470 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3id8 | MRK | Glucokinase | 2.7.1.2 | 0.470 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.470 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.470 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.469 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.469 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.469 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.468 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.468 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.468 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.468 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.468 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.467 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.467 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.467 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.467 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.466 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.466 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.466 | |
| 4r9u | ANP | Vitamin B12 import ATP-binding protein BtuD | / | 0.466 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.465 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.465 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.465 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.464 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.464 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.464 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.464 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.464 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.463 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.463 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.463 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.463 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.462 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.462 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.462 | |
| 1rbq | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.461 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.461 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4l8u | 9AZ | Serum albumin | / | 0.461 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.460 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.460 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2wpx | ACO | Orf14 | / | 0.459 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.459 | |
| 3gob | HXX | DdmC | / | 0.459 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.459 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.458 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.458 | |
| 2rew | REW | Peroxisome proliferator-activated receptor alpha | / | 0.458 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.458 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.458 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.458 | |
| 4hee | 14R | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.458 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.457 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.457 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.457 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.457 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.457 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.456 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 1mei | MOA | Inosine-5'-monophosphate dehydrogenase | / | 0.456 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.456 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.456 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.456 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.455 | |
| 1osv | CHC | Bile acid receptor | / | 0.455 | |
| 2z0y | SAM | Ribosomal RNA small subunit methyltransferase E | / | 0.455 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.455 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.455 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 3pt6 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.455 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2nmx | M25 | Carbonic anhydrase 1 | 4.2.1.1 | 0.454 | |
| 3e5r | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic | 1.2.1.12 | 0.454 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.454 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.454 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.454 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.454 | |
| 5a3c | NAD | SIR2 family protein | / | 0.454 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.453 | |
| 1v4s | MRK | Glucokinase | 2.7.1.2 | 0.453 | |
| 2zgy | GDP | Plasmid segregation protein ParM | / | 0.453 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.453 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 4nvk | 2NY | Peroxidase | / | 0.453 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.453 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1i6x | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.452 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.452 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.452 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.452 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.452 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.452 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.452 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 4ixc | 1JD | Glucokinase | 2.7.1.2 | 0.452 | |
| 1dvr | ATF | Adenylate kinase | / | 0.451 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.451 | |
| 1llq | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.451 | |
| 1mr9 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.451 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.451 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.451 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.451 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.451 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 3qpv | ADP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.451 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.451 | |
| 4bdh | WVI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.451 | |
| 4jk3 | NAD | Uncharacterized protein | / | 0.451 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.451 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.451 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1w1r | ZEA | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.450 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.450 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.450 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.450 | |
| 3ocp | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.450 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.450 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.450 | |
| 5es7 | FON | Linear gramicidin synthase subunit A | / | 0.450 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1gvh | FAD | Flavohemoprotein | / | 0.449 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 1nyx | DRF | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.449 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.449 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.449 | |
| 2d4e | NAD | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] | / | 0.449 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.449 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.449 | |
| 2oj9 | BMI | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.449 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.449 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.449 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.449 | |
| 3vkj | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.449 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.449 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.449 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.448 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.448 | |
| 1nbo | NAD | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.448 | |
| 1ojt | FAD | Dihydrolipoyl dehydrogenase | / | 0.448 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2q70 | DC8 | Estrogen receptor | / | 0.448 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.448 | |
| 3ieu | GDP | GTPase Era | / | 0.448 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.448 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4g3e | 0WC | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.448 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 5a3b | APR | SIR2 family protein | / | 0.448 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.447 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.447 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.447 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.447 | |
| 2ylr | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 3a7r | LAQ | Lipoate-protein ligase A | 6.3.1.20 | 0.447 | |
| 3cly | ACP | Fibroblast growth factor receptor 2 | / | 0.447 | |
| 3ea4 | FAB | Acetolactate synthase, chloroplastic | 2.2.1.6 | 0.447 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.447 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.447 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.447 | |
| 3zuy | TCH | Transporter | / | 0.447 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.447 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.447 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 4p8r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.447 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.447 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.446 | |
| 2bzs | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.446 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.446 | |
| 2owu | SAH | Diphthine synthase | / | 0.446 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3a20 | FMN | FMN-binding protein | / | 0.446 | |
| 3h3c | P1E | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.446 | |
| 3ksd | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.446 | |
| 3t37 | FAD | Pyridoxine 4-oxidase | / | 0.446 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.446 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4cfk | LY2 | Bromodomain-containing protein 4 | / | 0.446 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.446 | |
| 4mlh | VO2 | Glucokinase | 2.7.1.2 | 0.446 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.446 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.446 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1s9p | DES | Estrogen-related receptor gamma | / | 0.445 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.445 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.445 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.445 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.445 | |
| 2p2q | PRX | Acetyl-coenzyme A synthetase | / | 0.445 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.445 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3imx | B84 | Glucokinase | 2.7.1.2 | 0.445 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.445 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.445 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.445 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4ktc | 1X3 | Genome polyprotein | 3.4.21.98 | 0.445 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.445 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.445 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.444 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.444 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.444 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1py5 | PY1 | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.444 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.444 | |
| 2f5z | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.444 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.444 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.444 | |
| 2pkr | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.444 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.444 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 2yqu | FAD | Dihydrolipoyl dehydrogenase | / | 0.444 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.444 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.444 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.444 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.444 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.444 | |
| 4mle | VO1 | Glucokinase | 2.7.1.2 | 0.444 | |
| 4wlu | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.444 | |
| 1hon | GNH | Adenylosuccinate synthetase | / | 0.443 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 1nq5 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.443 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2b4r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.443 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2oo5 | TXD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.443 | |
| 2p2j | PRX | Acetyl-coenzyme A synthetase | / | 0.443 | |
| 3h0s | B38 | Acetyl-CoA carboxylase | / | 0.443 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.443 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.443 | |
| 4r8q | ADP | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 2.7.11.1 | 0.443 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.443 | |
| 5dp2 | NAP | CurF | / | 0.443 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.442 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.442 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.442 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 1sxj | ADP | Replication factor C subunit 5 | / | 0.442 | |
| 1u2d | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.442 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.442 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.442 | |
| 2gsd | NAD | Formate dehydrogenase | / | 0.442 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.442 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.442 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 3cgc | FAD | Coenzyme A disulfide reductase | / | 0.442 | |
| 3dxm | N24 | Actin-related protein 3 | / | 0.442 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.442 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.442 | |
| 4dx9 | SER_ALA_VAL_THR | Integrin beta-1 | / | 0.442 | |
| 4dx9 | SER_ALA_VAL_THR | Integrin beta-1-binding protein 1 | / | 0.442 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.442 | |
| 4l52 | 1UL | Mitogen-activated protein kinase kinase kinase 7 | 2.7.11.25 | 0.442 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.442 | |
| 4z9r | NAD | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.442 | |
| 1e3l | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.441 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.441 | |
| 1pzg | A3D | Lactate dehydrogenase | / | 0.441 | |
| 1qax | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.441 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.441 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.441 | |
| 2jd0 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.441 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.441 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.441 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.441 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.441 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.441 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.441 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.441 | |
| 4g17 | 0VN | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.441 | |
| 4l4x | NDP | AmphI | / | 0.441 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.441 | |
| 1f20 | NAP | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.440 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.440 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.440 | |
| 1u0h | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.440 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.440 | |
| 1ybm | NAP | Uncharacterized protein At5g02240 | / | 0.440 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.440 | |
| 2bdj | HET | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.440 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.440 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.440 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.440 | |
| 2imk | GTX | AGAP009194-PA | / | 0.440 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.440 | |
| 2nu9 | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.440 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.440 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 3dg8 | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.440 | |
| 3k6l | 2BB | Peptide deformylase | 3.5.1.88 | 0.440 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.440 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.440 | |
| 3zux | TCH | Transporter | / | 0.440 | |
| 4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4gpj | 0Q1 | Bromodomain-containing protein 4 | / | 0.440 | |
| 4ozn | ATP | Ammonium transporter | / | 0.440 | |
| 4rqz | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.440 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.440 |