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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5iotUMPFlavin-dependent thymidylate synthase2.1.1.148

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5iotUMPFlavin-dependent thymidylate synthase2.1.1.1481.000
2rc6NAPFerredoxin--NADP reductase/0.450
4c58824Cyclin-G-associated kinase2.7.11.10.446
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.444
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.444
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2an9GDPGuanylate kinase2.7.4.80.443
3q43D66M1 family aminopeptidase3.4.110.441
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.440
5ioqDURFlavin-dependent thymidylate synthase2.1.1.1480.440