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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.11.000
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.537
3hv5R24Mitogen-activated protein kinase 14/0.534
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.494
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.489
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
4aa0AA0Mitogen-activated protein kinase 14/0.451
2hyySTITyrosine-protein kinase ABL12.7.10.20.447
3kq7KQ7Mitogen-activated protein kinase 14/0.444
3hng8STVascular endothelial growth factor receptor 12.7.10.10.442