sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5gcn | COA | HAT A1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 5gcn | COA | HAT A1 | / | 1.000 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.524 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.516 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.510 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.509 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.508 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.506 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.506 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.503 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.501 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.501 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.500 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.498 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.497 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.497 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.497 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.496 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.496 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.495 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.495 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.492 | |
| 4j26 | EST | Estrogen receptor beta | / | 0.492 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.491 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.491 | |
| 5fsx | ADP | Uncharacterized protein | / | 0.491 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.490 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.488 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.487 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.486 | |
| 2b1z | 17M | Estrogen receptor | / | 0.485 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.485 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 3up3 | XCA | aceDAF-12 | / | 0.485 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.485 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.484 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.483 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.482 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.482 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.482 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.482 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 1qsn | COA | HAT A1 | / | 0.481 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.481 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.480 | |
| 1zky | 689 | Estrogen receptor | / | 0.480 | |
| 2ejz | SAH | Diphthine synthase | / | 0.480 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.480 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.479 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.479 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.479 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.478 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.478 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.478 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.477 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.476 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.476 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.476 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.476 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.476 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 4c3y | FAD | 3-ketosteroid dehydrogenase | / | 0.476 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.475 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.475 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.474 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.474 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.474 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.473 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.473 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.473 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.473 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.473 | |
| 3qly | 55V | Uncharacterized protein | / | 0.473 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.473 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 4pxm | EST | Estrogen receptor | / | 0.473 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.473 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.472 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.472 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.472 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.472 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.471 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.471 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.471 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.471 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.471 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.471 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.471 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.470 | |
| 4fr1 | 0V2 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.470 | |
| 4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.470 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.470 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.469 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.469 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.469 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 4tqq | UQ1 | Reaction center protein L chain | / | 0.469 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.468 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.468 | |
| 3oll | EST | Estrogen receptor beta | / | 0.468 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.467 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.467 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.467 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 2bxo | OPB | Serum albumin | / | 0.466 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.466 | |
| 2fk8 | SAM | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.466 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.466 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.466 | |
| 4giy | 0WY | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.466 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.466 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 2dvo | ITT | dITP/XTP pyrophosphatase | 3.6.1.19 | 0.465 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.465 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.465 | |
| 5dp2 | NAP | CurF | / | 0.465 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.465 | |
| 1cde | DZF | Phosphoribosylglycinamide formyltransferase | / | 0.464 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2rab | NAD | Glutathione amide reductase | / | 0.464 | |
| 2xke | WI2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.464 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.464 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.464 | |
| 3gb4 | D3M | DdmC | / | 0.464 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.463 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.463 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.463 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.463 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.463 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.463 | |
| 3dg8 | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.463 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.463 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.463 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.463 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.463 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.462 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.462 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.462 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.462 | |
| 2bju | IH4 | Plasmepsin-2 | 3.4.23.39 | 0.462 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 2xvw | 9NR | Serum albumin | / | 0.462 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.462 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.462 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.462 | |
| 3q95 | ESL | Estrogen receptor | / | 0.462 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.462 | |
| 1l2i | ETC | Estrogen receptor | / | 0.461 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 2fto | TMP | Thymidylate synthase | / | 0.461 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.461 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4l7v | SAH | Protein-L-isoaspartate O-methyltransferase | / | 0.461 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.461 | |
| 1l0o | ADP | Anti-sigma F factor | / | 0.460 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.460 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.460 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.460 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.459 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.459 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.459 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.459 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3eku | CY9 | Actin-5C | / | 0.459 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.459 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.459 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.459 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.459 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.459 | |
| 5cb5 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.459 | |
| 1gnw | GTX | Glutathione S-transferase F2 | 2.5.1.18 | 0.458 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1rgs | CMP | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.458 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.458 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1wpg | ADP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.458 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.458 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.458 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.458 | |
| 3b9l | AZZ | Serum albumin | / | 0.458 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.458 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.458 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.458 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.458 | |
| 3v2u | ATP | Protein GAL3 | / | 0.458 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.458 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.458 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.458 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1dtn | APG | Mandelate racemase | / | 0.457 | |
| 1ftl | DNQ | Glutamate receptor 2 | / | 0.457 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.457 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.457 | |
| 2yat | EEU | Estrogen receptor | / | 0.457 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.457 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3uud | EST | Estrogen receptor | / | 0.457 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 4uoh | ADP | Nucleoside diphosphate kinase | / | 0.457 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.457 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.456 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.456 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.456 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2bif | ANP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 0.456 | |
| 2cl5 | BIE | Catechol O-methyltransferase | 2.1.1.6 | 0.456 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.456 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.456 | |
| 2ocf | EST | Estrogen receptor | / | 0.456 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.456 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.456 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.456 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.456 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.456 | |
| 3up0 | D7S | aceDAF-12 | / | 0.456 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.456 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.456 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.455 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.455 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.455 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.455 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.455 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.455 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.455 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.455 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 3b7d | CNI | Glutamate receptor 2 | / | 0.455 | |
| 3q2m | CKI | Spectinomycin phosphotransferase | / | 0.455 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.455 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.455 | |
| 4l17 | DNQ | Glutamate receptor 2 | / | 0.455 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.455 | |
| 1fml | RTL | Retinol dehydratase | / | 0.454 | |
| 1x7r | GEN | Estrogen receptor | / | 0.454 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.454 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.454 | |
| 2od7 | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.454 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.454 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.454 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3med | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.454 | |
| 3reo | EUG | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.454 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 1a4z | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.453 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.453 | |
| 1n4s | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.453 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.453 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.453 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.453 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.453 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.453 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.453 | |
| 4afe | GGY | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.453 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.453 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.453 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.453 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.453 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.453 | |
| 1gwr | EST | Estrogen receptor | / | 0.452 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.452 | |
| 2fai | 459 | Estrogen receptor | / | 0.452 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.452 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.452 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.452 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.452 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.452 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4f1o | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.452 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1cde | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.451 | |
| 1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.451 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.451 | |
| 2g8d | UMP | Thymidylate synthase | / | 0.451 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3b05 | IPE | Isopentenyl-diphosphate delta-isomerase | / | 0.451 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.451 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.451 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.451 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.451 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.451 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.451 | |
| 4nmc | FAD | Bifunctional protein PutA | / | 0.451 | |
| 4qx5 | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.451 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 1s36 | CEI | Obelin | / | 0.450 | |
| 1s64 | 778 | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.450 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 2g44 | T3O | Estrogen receptor | / | 0.450 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2wky | IBC | Glutamate receptor ionotropic, kainate 1 | / | 0.450 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3kr6 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.450 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3ry2 | BTN | Streptavidin | / | 0.450 | |
| 3w0u | HPW | Lactoylglutathione lyase | 4.4.1.5 | 0.450 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.450 | |
| 4gh3 | 0EV | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.450 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4xiv | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.450 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.450 | |
| 3pbl | ETQ | D(3) dopamine receptor | / | 0.450 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.449 | |
| 1iay | AVG | 1-aminocyclopropane-1-carboxylate synthase 2 | 4.4.1.14 | 0.449 | |
| 1iiu | RTL | Retinol-binding protein 4 | / | 0.449 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.449 | |
| 1uxn | NAP | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.449 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3nmv | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.449 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.449 | |
| 4a5l | NDP | Thioredoxin reductase | / | 0.449 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.449 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.449 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1ne4 | RP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.448 | |
| 1ne6 | SP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.448 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.448 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2fdy | D4G | Cytochrome P450 2A6 | 1.14.13 | 0.448 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.448 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.448 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.448 | |
| 3g7f | UQ1 | Reaction center protein L chain | / | 0.448 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.448 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.448 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.448 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.448 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.448 | |
| 5ckw | ANP | Uncharacterized protein | / | 0.448 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.447 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.447 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.447 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.447 | |
| 2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 2qgt | EED | Estrogen receptor | / | 0.447 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.447 | |
| 2y88 | 2ER | Phosphoribosyl isomerase A | 5.3.1.16 | 0.447 | |
| 3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 4aos | NAP | Steroid monooxygenase | / | 0.447 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.447 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.447 | |
| 4iae | 1DX | Alr2278 protein | / | 0.447 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.447 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1f28 | UMP | Thymidylate synthase | 2.1.1.45 | 0.446 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.446 | |
| 1jjt | BDS | Beta-lactamase | / | 0.446 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.446 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.446 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.446 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.446 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.446 | |
| 2q70 | DC8 | Estrogen receptor | / | 0.446 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.446 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3h18 | PMS | Esterase/lipase | / | 0.446 | |
| 3huc | G97 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.446 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3zv5 | BPY | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.446 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.446 | |
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 0.446 | |
| 4hdr | DMD | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | / | 0.446 | |
| 4hdr | DMD | ArsB | / | 0.446 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.446 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.446 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.446 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.446 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.446 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.446 | |
| 5l7d | CLR | Smoothened homolog | / | 0.446 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.445 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
| 1mra | APG | Mandelate racemase | / | 0.445 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.445 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.445 | |
| 2acw | UPG | Glycosyltransferase | / | 0.445 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.445 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.445 | |
| 2qa8 | GEN | Estrogen receptor | / | 0.445 | |
| 2rtm | IMI | Streptavidin | / | 0.445 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3gl2 | D3M | DdmC | / | 0.445 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.445 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.445 | |
| 4ffr | ATP | Uncharacterized protein | / | 0.445 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.444 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.444 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.444 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.444 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2fjb | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.444 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 2p4i | MR9 | Angiopoietin-1 receptor | 2.7.10.1 | 0.444 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.444 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.444 | |
| 2zse | ACP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3cop | ADP | Glycogen synthase | 2.4.1.21 | 0.444 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.444 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.444 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.444 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.444 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.444 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.444 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.444 | |
| 1b4v | FAD | Cholesterol oxidase | 1.1.3.6 | 0.443 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 1n4q | LYS_CYS_VAL_ILE_LEU | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.443 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 1x7j | GEN | Estrogen receptor beta | / | 0.443 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 2e0i | FAD | DNA photolyase | / | 0.443 | |
| 2g5o | DRQ | Estrogen receptor | / | 0.443 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.443 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.443 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.443 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.443 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3p5s | AVU | CD38 molecule | / | 0.443 | |
| 3q5p | TAC | Multidrug-efflux transporter 1 regulator | / | 0.443 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.443 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.443 | |
| 4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.443 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.443 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4h6p | FMN | Chromate reductase | / | 0.443 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.443 | |
| 4opd | FDA | Conserved Archaeal protein | / | 0.443 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.443 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.443 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.442 | |
| 2a19 | ANP | Interferon-induced, double-stranded RNA-activated protein kinase | 2.7.11.1 | 0.442 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.442 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.442 | |
| 2xvv | 9DN | Serum albumin | / | 0.442 | |
| 3af2 | ACP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.442 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.442 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.442 | |
| 4eil | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.442 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.442 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.442 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4wud | ANP | DNA gyrase subunit B | / | 0.442 | |
| 4y1b | NAP | AntE | / | 0.442 | |
| 5epe | SAH | Uncharacterized protein | / | 0.442 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.441 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.441 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.441 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.441 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.441 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.441 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2z4j | DHT | Androgen receptor | / | 0.441 | |
| 3bej | MUF | Bile acid receptor | / | 0.441 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.441 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.441 | |
| 3p9t | TCL | Repressor | / | 0.441 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.441 | |
| 3qge | 26F | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.441 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3x06 | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.441 | |
| 4dpd | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 4kwh | NAP | Reductase homolog | / | 0.441 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.441 | |
| 1dfo | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.440 | |
| 1e3v | DXC | Steroid Delta-isomerase | 5.3.3.1 | 0.440 | |
| 1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.440 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.440 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.440 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 1tys | TMP | Thymidylate synthase | / | 0.440 | |
| 1u3r | 338 | Estrogen receptor beta | / | 0.440 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.440 | |
| 2j9g | ADP | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.440 | |
| 2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.440 | |
| 3b05 | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.440 | |
| 3cse | N22 | Uncharacterized protein | / | 0.440 | |
| 3dg8 | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.440 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.440 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.440 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.440 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.440 | |
| 4bew | ACP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.440 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.440 | |
| 5cho | FAD | Flavin reductase | / | 0.440 | |
| 5dxg | EST | Estrogen receptor | / | 0.440 |