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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5fkmTDCTetracycline repressor protein class D

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5fkmTDCTetracycline repressor protein class D/1.000
4auxXTCTetracycline repressor protein class D/0.675
2xpvMIYTetracycline repressor protein class D/0.660
5fklTDCTetracycline repressor protein class D/0.634
1orkATCTetracycline repressor protein class D/0.628
2trtTACTetracycline repressor protein class D/0.618
2o7oDXTTetracycline repressor protein class D/0.599
2xpwOTCTetracycline repressor protein class D/0.596
2xrlDXTTetracycline repressor protein class D/0.576
2xpuTDCTetracycline repressor protein class D/0.573
2vkeTACTetracycline repressor protein class D/0.571
4abzT1CTetracycline repressor protein class D/0.571
4b3aTACTetracycline repressor protein class D/0.560
2tctCTCTetracycline repressor protein class D/0.542
2x9dITCTetracycline repressor protein class D/0.532
4b1rITCTetracycline repressor protein class D/0.516
5fkoTDCTetracycline repressor protein class D/0.514
4v2gITCTetracycline repressor protein class D/0.501
2xb5I7TTetracycline repressor protein class D/0.495
4d7mTDCTetracycline repressor protein class D/0.491
5fknTDCTetracycline repressor protein class D/0.490
2vprTDCTetracycline repressor protein class H/0.481
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.470
2vkvTDCTetracycline repressor protein class D/0.469
2fj1CTCTetracycline repressor protein class D/0.459
2x6o2TCTetracycline repressor protein class D/0.447