sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5fi8 | ORO | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 5fi8 | ORO | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 1.000 | |
| 2dsg | SAH | Diphthine synthase | / | 0.494 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.489 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.488 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.486 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.486 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.485 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.484 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.483 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.479 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.479 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.475 | |
| 3eks | CY9 | Actin-5C | / | 0.475 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.475 | |
| 2ejz | SAH | Diphthine synthase | / | 0.474 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.474 | |
| 3w5u | FAD | Ferredoxin | / | 0.474 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.473 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.473 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.473 | |
| 2e4n | SAH | Diphthine synthase | / | 0.473 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.473 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.472 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.472 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.471 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.470 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.470 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 2p6l | SAH | Diphthine synthase | / | 0.469 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.469 | |
| 3eku | CY9 | Actin-5C | / | 0.469 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.468 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.467 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.467 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.467 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.466 | |
| 2x86 | ADP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.466 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.466 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.466 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.466 | |
| 2hut | SAH | Diphthine synthase | / | 0.465 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.465 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.465 | |
| 2e8h | SAH | Diphthine synthase | / | 0.464 | |
| 2emu | SAH | Diphthine synthase | / | 0.464 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.464 | |
| 2pcm | SAH | Diphthine synthase | / | 0.464 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.463 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.463 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.463 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.463 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.463 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.463 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.463 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.462 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.462 | |
| 3v2u | ATP | Protein GAL3 | / | 0.462 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.462 | |
| 4e2d | FMN | Dehydrogenase | / | 0.462 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.462 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.461 | |
| 2huv | SAH | Diphthine synthase | / | 0.461 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.461 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.461 | |
| 3vf3 | 0GS | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4f9g | C2E | Stimulator of interferon genes protein | / | 0.461 | |
| 5ilw | URI | Ribosome inactivating protein | / | 0.461 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.460 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.460 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.460 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.460 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.460 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.460 | |
| 4b78 | KGG | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4pgh | SAM | Caffeic acid O-methyltransferase | / | 0.459 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.458 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.458 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.458 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.458 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.457 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.457 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.456 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.456 | |
| 2e07 | SAH | Diphthine synthase | / | 0.456 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.456 | |
| 2ek4 | SAH | Diphthine synthase | / | 0.456 | |
| 2eld | SAH | Diphthine synthase | / | 0.456 | |
| 2web | PP4 | Penicillopepsin-1 | 3.4.23.20 | 0.456 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.456 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.456 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.456 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.456 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.456 | |
| 4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.455 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.455 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.455 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.455 | |
| 1lrk | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.454 | |
| 2e15 | SAH | Diphthine synthase | / | 0.454 | |
| 2egs | SAH | Diphthine synthase | / | 0.454 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.454 | |
| 2owf | SAH | Diphthine synthase | / | 0.454 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.454 | |
| 2yj4 | ATP | Copper-transporting ATPase | / | 0.454 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.454 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.454 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.454 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.454 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.454 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.454 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.454 | |
| 1wng | SAH | Diphthine synthase | / | 0.453 | |
| 1xp8 | AGS | Protein RecA | / | 0.453 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.453 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.453 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.453 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.453 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.453 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 5cho | FAD | Flavin reductase | / | 0.453 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.452 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.452 | |
| 1wm1 | PTB | Proline iminopeptidase | 3.4.11.5 | 0.452 | |
| 2hux | SAH | Diphthine synthase | / | 0.452 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.452 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.452 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.452 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.452 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2dxi | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.451 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.451 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.451 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.451 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.451 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.451 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.451 | |
| 4f97 | VDO | Putative glycosyltransferase | / | 0.451 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.450 | |
| 1g9d | BAB | Botulinum neurotoxin type B | 3.4.24.69 | 0.450 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 1iy8 | NAD | Levodione reductase | / | 0.450 | |
| 1ri1 | GTG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.450 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.450 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 2x8g | FAD | Thioredoxin glutathione reductase | / | 0.450 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.450 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.450 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.450 | |
| 4hrq | AZG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.450 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.450 | |
| 4rel | KMP | Glycosyltransferase | / | 0.450 | |
| 4wxg | 2BO | Serine hydroxymethyltransferase | / | 0.450 | |
| 5itz | GTP | Tubulin alpha-1B chain | / | 0.450 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.449 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.449 | |
| 2e8r | SAH | Diphthine synthase | / | 0.449 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.449 | |
| 3qfa | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.449 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.449 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.449 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.449 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.449 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.448 | |
| 1xvv | CCQ | L-carnitine CoA-transferase | / | 0.448 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2fhj | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.448 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.448 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.448 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.448 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.448 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4xwt | U5P | Ribonuclease J | / | 0.448 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.447 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2xfy | ACX | Beta-amylase | 3.2.1.2 | 0.447 | |
| 2z6r | SAH | Diphthine synthase | / | 0.447 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.447 | |
| 3c4h | DRL | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.447 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.447 | |
| 3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.447 | |
| 4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.447 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.447 | |
| 4yfy | 1YJ | VioF | / | 0.447 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.446 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.446 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.446 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.446 | |
| 2en5 | SAH | Diphthine synthase | / | 0.446 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.446 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.446 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.446 | |
| 2zr9 | DTP | Protein RecA | / | 0.446 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.446 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.446 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.446 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.446 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.446 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.446 | |
| 3ntr | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.446 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.446 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.446 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.446 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1ppl | 1Z7 | Penicillopepsin-1 | 3.4.23.20 | 0.445 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.445 | |
| 2iml | FMN | Uncharacterized protein | / | 0.445 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.445 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.445 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.445 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.445 | |
| 4jiq | 1L5 | GTN Reductase | / | 0.445 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.445 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.445 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1vjt | NAD | Alpha-glucosidase, putative | / | 0.444 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.444 | |
| 2el3 | SAH | Diphthine synthase | / | 0.444 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.444 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.444 | |
| 2owg | SAH | Diphthine synthase | / | 0.444 | |
| 2pcg | SAH | Diphthine synthase | / | 0.444 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.444 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.444 | |
| 3i6i | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.444 | |
| 3tjl | FMN | NADPH dehydrogenase | / | 0.444 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.444 | |
| 1gaq | FAD | Ferredoxin | / | 0.443 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.443 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.443 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.443 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.443 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.443 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.443 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.442 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.442 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.442 | |
| 2dek | SAH | Diphthine synthase | / | 0.442 | |
| 2ele | SAH | Diphthine synthase | / | 0.442 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.442 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.442 | |
| 2pca | SAH | Diphthine synthase | / | 0.442 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.442 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 4a61 | ANP | Plasmid segregation protein ParM | / | 0.442 | |
| 4hmx | FMN | Pyridoxamine 5'-phosphate oxidase | / | 0.442 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.442 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.442 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.442 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1m4i | COA | Aminoglycoside 2'-N-acetyltransferase | 2.3.1 | 0.441 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.441 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.441 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.441 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.441 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.441 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 3i6q | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.441 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.441 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.441 | |
| 4to0 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.441 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.441 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.441 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.440 | |
| 1ozp | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.440 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.440 | |
| 2dsh | SAH | Diphthine synthase | / | 0.440 | |
| 2e8q | SAH | Diphthine synthase | / | 0.440 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.440 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2owk | SAH | Diphthine synthase | / | 0.440 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.440 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.440 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4y3j | HIC | Endothiapepsin | 3.4.23.22 | 0.440 | |
| 5dn1 | AMZ | Phosphoribosyl isomerase A | 5.3.1.16 | 0.440 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.440 |