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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5f0a1FBcGMP-dependent protein kinase, putative

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5f0a1FBcGMP-dependent protein kinase, putative/1.000
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.482
4yuqKS1Calmodulin-like domain protein kinase/0.481
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.473
3gubGUBDeath-associated protein kinase 12.7.11.10.472
3s4qNK0Mitogen-activated protein kinase 14/0.471
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.467
5auuLU2Death-associated protein kinase 12.7.11.10.466
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.465
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.465
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.465
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.464
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.463
3l8xN4DMitogen-activated protein kinase 14/0.463
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.462
4c35NU3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.460
3bhy7CPDeath-associated protein kinase 3/0.460
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.460
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.459
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.459
5auwQUEDeath-associated protein kinase 12.7.11.10.459
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4cztCPSCBL-interacting serine/threonine-protein kinase 232.7.11.10.457
5auzGENDeath-associated protein kinase 12.7.11.10.457
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.456
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.456
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.455
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.454
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.453
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.453
4c02TAKActivin receptor type-12.7.11.300.453
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.452
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.452
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.452
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.452
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.452
1wvxBD4Death-associated protein kinase 12.7.11.10.451
3igoANPCalmodulin-domain protein kinase 1, putative/0.451
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.451
2hog710Serine/threonine-protein kinase Chk12.7.11.10.450
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.450
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.450
4kin1M8Mitogen-activated protein kinase 14/0.450
4loqSB4Mitogen-activated protein kinase 14/0.450
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.449
1ouk084Mitogen-activated protein kinase 14/0.449
2itqITQEpidermal growth factor receptor2.7.10.10.449
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.449
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.449
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.449
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.449
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.448
2vrx447Aurora kinase B-A2.7.11.10.448
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.448
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.448
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.448
3vryB43Tyrosine-protein kinase HCK2.7.10.20.448
4l445FIRibosomal protein S6 kinase beta-12.7.11.10.448
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.447
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.447
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.447
4ih8B43Calmodulin-domain protein kinase 1/0.447
3q5iANPProtein kinase, putative/0.446
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4gw83RASerine/threonine-protein kinase pim-12.7.11.10.446
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.445
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.444
2uzlC94Cyclin-dependent kinase 22.7.11.220.444
3a62STURibosomal protein S6 kinase beta-12.7.11.10.444
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.443
4dpwAGSMevalonate diphosphate decarboxylase/0.443
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.442
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.442
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.442
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.442
4jrvKJVEpidermal growth factor receptor2.7.10.10.442
2xizXIZSerine/threonine-protein kinase pim-12.7.11.10.441
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.441
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.441
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.440
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.440
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.440
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.440
5da9AGSUncharacterized protein/0.440