sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
5e9w	SAH	mRNA cap guanine-N7 methyltransferase	2.1.1.56

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
5e9w	SAH	mRNA cap guanine-N7 methyltransferase	2.1.1.56	1.000
1ri4	SAM	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.533
1ri1	GTG	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.484
5e8j	SAH	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.480
1ri3	SAH	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.468
3ruc	NAD	UDP-N-acetylglucosamine 4-epimerase	/	0.462
1bxk	NAD	dTDP-glucose 4,6-dehydratase 2	/	0.461
1dhi	MTX	Dihydrofolate reductase	1.5.1.3	0.455
4a6r	TA8	Probable aminotransferase	/	0.452
4ge4	0KE	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	2.6.1.39	0.449
2zsa	ADP	Pantothenate kinase	2.7.1.33	0.445
1d2h	SAH	Glycine N-methyltransferase	2.1.1.20	0.444
1dxo	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.443
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.442
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.441
2iyf	ERY	Oleandomycin glycosyltransferase	2.4.1	0.441
3rue	NAD	UDP-N-acetylglucosamine 4-epimerase	/	0.441