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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5e8ySTUTGF-beta receptor type-22.7.11.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5e8ySTUTGF-beta receptor type-22.7.11.301.000
4dgnLU2Casein kinase II subunit alpha2.7.11.10.499
4j95ACPFibroblast growth factor receptor 2/0.497
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.494
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.493
3hmm855TGF-beta receptor type-12.7.11.300.491
4jia1K3Tyrosine-protein kinase JAK2/0.491
4aqc88ATyrosine-protein kinase JAK2/0.490
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.489
3i60E86Mitogen-activated protein kinase 12.7.11.240.488
3kvxFMYMitogen-activated protein kinase 102.7.11.240.488
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.487
4fv6E57Mitogen-activated protein kinase 12.7.11.240.482
3rkb12ZCyclin-dependent kinase 22.7.11.220.481
1bygSTUTyrosine-protein kinase CSK/0.480
3lpbNVBTyrosine-protein kinase JAK2/0.480
4grb0XGCasein kinase II subunit alpha2.7.11.10.480
4hge15VTyrosine-protein kinase JAK2/0.479
5e92ANPTGF-beta receptor type-22.7.11.300.478
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.476
3be9P04Casein kinase II subunit alpha2.7.11.10.476
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.475
4btjADPTau-tubulin kinase 12.7.11.10.474
4qnyANPMitogen activated protein kinase, putative/0.472
2wouZZFTGF-beta receptor type-12.7.11.300.471
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.469
4j98ACPFibroblast growth factor receptor 2/0.469
2p33J07Mitogen-activated protein kinase 102.7.11.240.467
3nieANPMitogen-activated protein kinase/0.467
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.467
4dgmAGICasein kinase II subunit alpha2.7.11.10.465
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.464
1vjy460TGF-beta receptor type-12.7.11.300.464
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.464
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.464
4ocvANPAminoglycoside phosphotransferase/0.464
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.463
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.463
4e6d0NUTyrosine-protein kinase JAK2/0.463
1om1IQACasein kinase II subunit alpha2.7.11.10.462
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.462
2pvlP55Casein kinase II subunit alpha2.7.11.10.461
3ezvEZVCyclin-dependent kinase 22.7.11.220.461
4f9b0SYCell division cycle 7-related protein kinase2.7.11.10.461
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.461
4g1wG1WMitogen-activated protein kinase 82.7.11.240.461
2pvmP29Casein kinase II subunit alpha2.7.11.10.460
1w0xOLOCyclin-dependent kinase 22.7.11.220.459
4f081RSTyrosine-protein kinase JAK2/0.459
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.459
3rak03ZCyclin-dependent kinase 22.7.11.220.458
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.458
1pxmCK5Cyclin-dependent kinase 22.7.11.220.457
4btjATPTau-tubulin kinase 12.7.11.10.457
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
4gmy0X5Tyrosine-protein kinase JAK2/0.456
4y93746Tyrosine-protein kinase/0.456
1pmn984Mitogen-activated protein kinase 102.7.11.240.455
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.455
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.454
3at4CCKCasein kinase II subunit alpha2.7.11.10.454
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.454
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.454
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.453
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3cgfJNFMitogen-activated protein kinase 102.7.11.240.453
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.453
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.452
3q9xEMOCasein kinase II subunit alpha2.7.11.10.452
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.452
4ockANPN-acetylhexosamine 1-kinase2.7.1.1620.452
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.451
4h3qANPMitogen-activated protein kinase 12.7.11.240.451
4lfiGNPCasein kinase II subunit alpha2.7.11.10.451
2pvhP19Casein kinase II subunit alpha2.7.11.10.450
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2vv9IM9Cyclin-dependent kinase 22.7.11.220.450
3ncz3NCRho-associated protein kinase 12.7.11.10.450
3w2sW2REpidermal growth factor receptor2.7.10.10.450
5dnrATPAurora kinase A2.7.11.10.450
1fvv107Cyclin-dependent kinase 22.7.11.220.449
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.449
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.449
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.448
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.448
3u4uLNHCasein kinase II subunit alpha2.7.11.10.448
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.448
5e8xSTUTGF-beta receptor type-12.7.11.300.448
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2pvnP63Casein kinase II subunit alpha2.7.11.10.447
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2w17I19Cyclin-dependent kinase 22.7.11.220.446
3mtfA3FActivin receptor type-12.7.11.300.446
1dawANPCasein kinase II subunit alpha2.7.11.10.445
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.445
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2y9qANPMitogen-activated protein kinase 12.7.11.240.445
3ttiKBIMitogen-activated protein kinase 102.7.11.240.445
4anmWULCasein kinase II subunit alpha2.7.11.10.445
4fv9E71Mitogen-activated protein kinase 12.7.11.240.445
1m2pHNACasein kinase II subunit alpha2.7.11.10.444
3my5RFZCyclin-dependent kinase 22.7.11.220.444
4bgg844Activin receptor type-12.7.11.300.444
4hvi19STyrosine-protein kinase JAK32.7.10.20.444
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.444
2xvdAS6Ephrin type-B receptor 42.7.10.10.443
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.443
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4jboWPHAurora kinase A2.7.11.10.442
3gxlQIGTGF-beta receptor type-12.7.11.300.441
3r1yX76Cyclin-dependent kinase 22.7.11.220.441
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.441
4ysjADPCalmodulin-like domain protein kinase/0.441
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.440
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440