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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5e8wSTUTGF-beta receptor type-12.7.11.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5e8wSTUTGF-beta receptor type-12.7.11.301.000
2wotZZGTGF-beta receptor type-12.7.11.300.599
3gxlQIGTGF-beta receptor type-12.7.11.300.589
1rw8580TGF-beta receptor type-12.7.11.300.540
1bygSTUTyrosine-protein kinase CSK/0.518
4c02TAKActivin receptor type-12.7.11.300.517
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.515
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.505
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.505
4dymIYZActivin receptor type-12.7.11.300.504
4qmpDKISerine/threonine-protein kinase 242.7.11.10.502
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.501
1py5PY1TGF-beta receptor type-12.7.11.300.499
5e8xSTUTGF-beta receptor type-12.7.11.300.499
2qo9ANPEphrin type-A receptor 32.7.10.10.495
4bgg844Activin receptor type-12.7.11.300.494
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.493
4gmy0X5Tyrosine-protein kinase JAK2/0.491
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.486
2iw84SPCyclin-dependent kinase 22.7.11.220.484
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.482
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.482
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.482
1u54ACPActivated CDC42 kinase 1/0.481
3gubGUBDeath-associated protein kinase 12.7.11.10.477
4c61LMMTyrosine-protein kinase JAK2/0.477
4riyADPEpidermal growth factor receptor2.7.10.10.477
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.476
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.476
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.475
3zewSTUEphrin type-B receptor 42.7.10.10.475
4i22IREEpidermal growth factor receptor2.7.10.10.475
5e92ANPTGF-beta receptor type-22.7.11.300.475
2iw94SPCyclin-dependent kinase 22.7.11.220.474
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.474
3vryB43Tyrosine-protein kinase HCK2.7.10.20.474
4jia1K3Tyrosine-protein kinase JAK2/0.474
4qmzB49Serine/threonine-protein kinase 242.7.11.10.474
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.473
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.473
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.473
2yn8STUEphrin type-B receptor 42.7.10.10.471
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.471
2j0m4STFocal adhesion kinase 12.7.10.20.470
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.470
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
2xikJ60Serine/threonine-protein kinase 252.7.11.10.469
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.469
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.468
2vx17X8Ephrin type-B receptor 42.7.10.10.468
3i60E86Mitogen-activated protein kinase 12.7.11.240.468
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.468
4j97ACPFibroblast growth factor receptor 2/0.468
1xjdSTUProtein kinase C theta type2.7.11.130.467
3be9P04Casein kinase II subunit alpha2.7.11.10.467
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.467
4dgnLU2Casein kinase II subunit alpha2.7.11.10.467
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.467
2x1nX1NCyclin-dependent kinase 22.7.11.220.466
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.466
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.466
1m2pHNACasein kinase II subunit alpha2.7.11.10.465
2vx07X7Ephrin type-B receptor 42.7.10.10.465
3oom507Activin receptor type-12.7.11.300.465
4bb432WEphrin type-B receptor 42.7.10.10.465
4e4m0NHTyrosine-protein kinase JAK2/0.465
1h1s4SPCyclin-dependent kinase 22.7.11.220.464
4erwSTUCyclin-dependent kinase 22.7.11.220.464
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.464
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.463
2vwz7X6Ephrin type-B receptor 42.7.10.10.463
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.463
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.462
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.462
2of4979Tyrosine-protein kinase Lck2.7.10.20.462
2xa4AZ5Tyrosine-protein kinase JAK2/0.462
3ddpRC8Cyclin-dependent kinase 22.7.11.220.462
4ewhT77Activated CDC42 kinase 1/0.462
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.462
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.461
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.461
4hvh19RTyrosine-protein kinase JAK32.7.10.20.461
1jpaANPEphrin type-B receptor 22.7.10.10.460
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
2vwx7X4Ephrin type-B receptor 42.7.10.10.460
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.460
3l8p0CEAngiopoietin-1 receptor2.7.10.10.460
4jqeANPCasein kinase II subunit alpha2.7.11.10.460
4qnaX11Serine/threonine-protein kinase 242.7.11.10.460
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.459
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.458
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.458
2x9fX9FEphrin type-B receptor 42.7.10.10.458
4gk2L66Ephrin type-A receptor 32.7.10.10.458
4nj32KDCyclin-dependent kinase 22.7.11.220.458
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.457
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.457
4lopSB4Mitogen-activated protein kinase 14/0.457
1pyePM1Cyclin-dependent kinase 22.7.11.220.456
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.456
3il1B5DGlutamate receptor 2/0.456
4dgo0JWCasein kinase II subunit alpha2.7.11.10.456
2i40BLZCyclin-dependent kinase 22.7.11.220.455
3gggNADPrephenate dehydrogenase/0.455
3uli1N3Cyclin-dependent kinase 22.7.11.220.455
2znq401Peroxisome proliferator-activated receptor delta/0.454
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.454
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.454
4g2fC07Ephrin type-A receptor 32.7.10.10.454
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.454
1e9hINRCyclin-dependent kinase 22.7.11.220.453
2in6839Wee1-like protein kinase2.7.10.20.453
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.453
4yuqKS1Calmodulin-like domain protein kinase/0.453
1fwkADPHomoserine kinase2.7.1.390.452
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.452
2vwy7X5Ephrin type-B receptor 42.7.10.10.452
2y6o1N1Ephrin type-A receptor 42.7.10.10.452
2zdt46CMitogen-activated protein kinase 102.7.11.240.452
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.452
4hvi19STyrosine-protein kinase JAK32.7.10.20.452
3t2kFADSulfide-quinone reductase/0.451
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.451
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
1om1IQACasein kinase II subunit alpha2.7.11.10.450
1pkdUCNCyclin-dependent kinase 22.7.11.220.450
2pmdGNPTranslation initiation factor 2 subunit gamma/0.450
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
3rk507ZCyclin-dependent kinase 22.7.11.220.450
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.450
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
1oiyN41Cyclin-dependent kinase 22.7.11.220.449
4hnf16WCasein kinase I isoform delta2.7.11.10.449
4kbk1QGCasein kinase I isoform delta2.7.11.10.449
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.449
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.448
3ggfGVDSerine/threonine-protein kinase 26/0.448
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.448
4k33ACPFibroblast growth factor receptor 32.7.10.10.448
1m2qMNXCasein kinase II subunit alpha2.7.11.10.447
1xkkFMMEpidermal growth factor receptor2.7.10.10.447
2of2547Tyrosine-protein kinase Lck2.7.10.20.447
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.447
3t8oATPRhodopsin kinase/0.447
3zep1NXTyrosine-protein kinase JAK32.7.10.20.447
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.447
4hge15VTyrosine-protein kinase JAK2/0.447
5drdATPAurora kinase A2.7.11.10.447
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1di8DTQCyclin-dependent kinase 22.7.11.220.446
1h1r6CPCyclin-dependent kinase 22.7.11.220.446
2q61SF1Peroxisome proliferator-activated receptor gamma/0.446
3iok1P6Tyrosine-protein kinase JAK2/0.446
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.446
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1vyw292Cyclin-dependent kinase 22.7.11.220.445
2gjlFMNNitronate monooxygenase1.13.12.160.445
2wxvWXVCyclin-dependent kinase 22.7.11.220.445
3bi6396Wee1-like protein kinase2.7.10.20.445
3mvl38PMitogen-activated protein kinase 14/0.445
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.445
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.445
4gk3L87Ephrin type-A receptor 32.7.10.10.445
1gih1PUCyclin-dependent kinase 22.7.11.220.444
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.444
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.444
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.444
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.444
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.444
3s1dZIRCytokinin dehydrogenase 11.5.99.120.444
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.444
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.444
4nk92K5Fibroblast growth factor receptor 1/0.444
1oi9N20Cyclin-dependent kinase 22.7.11.220.443
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.443
2j0k4STFocal adhesion kinase 12.7.10.20.443
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.443
4qmlANPSerine/threonine-protein kinase 242.7.11.10.443
4uymVOR14-alpha sterol demethylase Cyp51B/0.443
4y8wSTRSteroid 21-hydroxylase/0.443
5e8ySTUTGF-beta receptor type-22.7.11.300.443
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.442
2j0j4STFocal adhesion kinase 12.7.10.20.442
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.442
2w05FRTCyclin-dependent kinase 22.7.11.220.442
3bhtMFRCyclin-dependent kinase 22.7.11.220.442
3kvxFMYMitogen-activated protein kinase 102.7.11.240.442
3ttjJBIMitogen-activated protein kinase 102.7.11.240.442
3uzp0CKCasein kinase I isoform delta2.7.11.10.442
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.442
4bcpT3CCyclin-dependent kinase 22.7.11.220.442
4fod0UVALK tyrosine kinase receptor2.7.10.10.442
2b7aIZATyrosine-protein kinase JAK2/0.441
2cchATPCyclin-dependent kinase 22.7.11.220.441
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.441
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.441
4fob0USALK tyrosine kinase receptor2.7.10.10.441
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.441
4g160VMCasein kinase I isoform gamma-32.7.11.10.441
4hvg19QTyrosine-protein kinase JAK32.7.10.20.441
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.441
4kb81QNCasein kinase I isoform delta2.7.11.10.441
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.441
2eufLQQCyclin-dependent kinase 62.7.11.220.440
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.440
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.440
4b99R4LMitogen-activated protein kinase 72.7.11.240.440
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.440
4jq8KJ8Epidermal growth factor receptor2.7.10.10.440