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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ds309LPoly [ADP-ribose] polymerase 12.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5ds309LPoly [ADP-ribose] polymerase 12.4.2.301.000
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.596
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.588
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.583
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.572
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.569
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.565
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.563
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.560
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.557
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.554
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.544
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.543
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.533
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.529
4pnmNU1Tankyrase-22.4.2.300.519
1xk9P34Exotoxin A2.4.2.360.518
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.509
3l3lL3LPoly [ADP-ribose] polymerase 12.4.2.300.509
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.300.506
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.506
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.501
4tjy3GNTankyrase-22.4.2.300.501
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.500
1a26CNAPoly [ADP-ribose] polymerase 12.4.2.300.493
4bj9UHBTankyrase-22.4.2.300.487
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.486
3b82NADExotoxin A2.4.2.360.468
4k4eK4ETankyrase-12.4.2.300.468
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.465
4bjbP34Tankyrase-22.4.2.300.464
3geyP34Poly [ADP-ribose] polymerase 152.4.2.300.459
2zitNADExotoxin A2.4.2.360.450
4bjcRPBTankyrase-22.4.2.300.449