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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5dbvCOAAldehyde Dehydrogenase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5dbvCOAAldehyde Dehydrogenase/1.000
4c3sNADAldehyde Dehydrogenase/0.533
4dieC5PCytidylate kinase/0.459
3qwbNDPProbable quinone oxidoreductase1.6.5.50.456
2ylwNAPPhenylacetone monooxygenase1.14.13.920.454
3och2MXDihydrofolate reductase1.5.1.30.452
1xe55FEPlasmepsin-23.4.23.390.449
4bfvZVVPantothenate kinase2.7.1.330.449
5br7FADUDP-galactopyranose mutase/0.449
3toxNAPPutative oxidoreductase/0.446
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.445
2ym1NAPPhenylacetone monooxygenase1.14.13.920.445
1jolFFODihydrofolate reductase1.5.1.30.444
3b6zCO7Enoyl reductase LovC10.443
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.443
5ez7FADProbable FAD-dependent oxidoreductase PA4991/0.443
1xl5190Gag-Pol polyprotein3.4.23.160.442
4ejmNAPPutative zinc-binding dehydrogenase/0.442
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.441
3mzhCMPCRP-like cAMP-activated global transcriptional regulator/0.441
3pm9FADPutative oxidoreductase/0.441
4kl1PCGPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.441
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
4cpdNADAlcohol dehydrogenase/0.440
4d04NAPPhenylacetone monooxygenase1.14.13.920.440