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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ctsCMCCitrate synthase, mitochondrial2.3.3.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5ctsCMCCitrate synthase, mitochondrial2.3.3.11.000
6ctsCICCitrate synthase, mitochondrial2.3.3.10.796
2ctsCOACitrate synthase, mitochondrial2.3.3.10.662
1cscCMCCitrate synthase, mitochondrial2.3.3.10.600
3cscACOCitrate synthase, mitochondrial2.3.3.10.508