sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
5ccx	SAH	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A	2.1.1.220

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
5ccx	SAH	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A	2.1.1.220	1.000
5ccb	SAH	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A	2.1.1.220	0.582
4ymg	SAM	Putative SAM-dependent O-methyltranferase	/	0.460
3lhd	SAH	tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI	2.1.1.219	0.455
3up3	XCA	aceDAF-12	/	0.450
2dpm	SAM	Modification methylase DpnIIA	2.1.1.72	0.449
2pwy	SAH	tRNA (adenine(58)-N(1))-methyltransferase TrmI	2.1.1.220	0.447
1siq	FAD	Glutaryl-CoA dehydrogenase, mitochondrial	1.3.8.6	0.444
4ft4	SAH	DNA (cytosine-5)-methyltransferase 1	2.1.1.37	0.442
1kuy	COT	Serotonin N-acetyltransferase	/	0.440
2rc6	NAP	Ferredoxin--NADP reductase	/	0.440