sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5cae | COA | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 6.2.1.4 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 5cae | COA | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 6.2.1.4 | 1.000 | |
| 4xx0 | COA | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 6.2.1.4 | 0.526 | |
| 2oby | NAP | Quinone oxidoreductase PIG3 | 1 | 0.493 | |
| 1osv | CHC | Bile acid receptor | / | 0.470 | |
| 1eio | GCH | Gastrotropin | / | 0.458 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 3l9h | EMQ | Kinesin-like protein KIF11 | / | 0.452 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.450 | |
| 3up0 | D7S | aceDAF-12 | / | 0.450 | |
| 1t0l | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.449 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.449 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.449 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.449 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.449 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.446 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.446 | |
| 3ms4 | 21N | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.445 | |
| 2d4v | NAD | Isocitrate dehydrogenase [NADP] | / | 0.443 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.443 | |
| 1psd | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.442 | |
| 2eq6 | FAD | Dihydrolipoyl dehydrogenase | / | 0.442 | |
| 4e2d | FMN | Dehydrogenase | / | 0.442 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.442 | |
| 2j8z | NAP | Quinone oxidoreductase PIG3 | 1 | 0.441 | |
| 1ict | T44 | Transthyretin | / | 0.440 | |
| 3o7l | ANP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 |